Electroneutral sodium bicarbonate exchanger 1 explained

Electroneutral sodium bicarbonate exchanger 1 is a protein that in humans is encoded by the SLC4A8 gene.^{[1] [2]}

See also

• Solute carrier family
• cotransporter

Interactions

SLC4A8 has been shown to interact with Sodium-hydrogen antiporter 3 regulator 1^{[3] [4]} and Cystic fibrosis transmembrane conductance regulator.^[4]

References

Further reading

• Soleimani M . Na⁺:HCO₃⁻ cs (NBC): expression and regulation in the kidney . J. Nephrol. . 15 . S32–40 . 2002 . Suppl 5 . 12027220 .
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 1356129 . 10.1101/gr.4039406 .
• Huda Zoghbi . Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Loiselle FB, Morgan PE, Alvarez BV, Casey JR . Regulation of the human NBC3 Na⁺/HCO₃⁻ cotransporter by carbonic anhydrase II and PKA . Am. J. Physiol., Cell Physiol. . 286 . 6 . C1423–33 . 2004 . 14736710 . 10.1152/ajpcell.00382.2003 .
• Pushkin A, Abuladze N, Newman D, Muronets V, Sassani P, Tatishchev S, Kurtz I . The COOH termini of NBC3 and the 56-kDa H⁺-ATPase subunit are PDZ motifs involved in their interaction . Am. J. Physiol., Cell Physiol. . 284 . 3 . C667–73 . 2003 . 12444018 . 10.1152/ajpcell.00225.2002 . 7070088 .
• Park M, Ko SB, Choi JY, Muallem G, Thomas PJ, Pushkin A, Lee MS, Kim JY, Lee MG, Muallem S, Kurtz I . The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO₃⁻ salvage transporter human Na⁺-HCO₃⁻ cotransport isoform 3 . J. Biol. Chem. . 277 . 52 . 50503–9 . 2003 . 12403779 . 10.1074/jbc.M201862200 . free .
• Gresz V, Kwon TH, Vorum H, Zelles T, Kurtz I, Steward MC, Aalkjaer C, Nielsen S . Immunolocalization of electroneutral Na⁺-HCO cotransporters in human and rat salivary glands . Am. J. Physiol. Gastrointest. Liver Physiol. . 283 . 2 . G473–80 . 2002 . 12121896 . 10.1152/ajpgi.00421.2001 .
• Amlal H, Burnham CE, Soleimani M . Characterization of Na⁺/HCO₃⁻ cotransporter isoform NBC-3 . Am. J. Physiol. . 276 . 6 Pt 2 . F903–13 . 1999 . 10362779 . 10.1152/ajprenal.1999.276.6.F903.
• Pushkin A, Abuladze N, Lee I, Newman D, Hwang J, Kurtz I . Cloning, tissue distribution, genomic organization, and functional characterization of NBC3, a new member of the sodium bicarbonate cotransporter family . J. Biol. Chem. . 274 . 23 . 16569–75 . 1999 . 10347222 . 10.1074/jbc.274.23.16569 . free .
• Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Res. . 5 . 5 . 277–86 . 1999 . 9872452 . 10.1093/dnares/5.5.277 . free .

Notes and References

1. Grichtchenko II, Choi I, Zhong X, Bray-Ward P, Russell JM, Boron WF . Cloning, characterization, and chromosomal mapping of a human electroneutral Na⁺-driven Cl⁻HCO₃ exchanger . J Biol Chem . 276 . 11 . 8358–63 . May 2001 . 11133997 . 10.1074/jbc.C000716200 . free .
2. Web site: Entrez Gene: SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8.
3. Pushkin A, Abuladze N, Newman D, Muronets V, Sassani P, Tatishchev S, Kurtz I . The COOH termini of NBC3 and the 56-kDa H⁺-ATPase subunit are PDZ motifs involved in their interaction . Am. J. Physiol., Cell Physiol. . 284 . 3 . C667–73 . March 2003 . 12444018 . 10.1152/ajpcell.00225.2002 . 7070088 .
4. Park M, Ko SB, Choi JY, Muallem G, Thomas PJ, Pushkin A, Lee MS, Kim JY, Lee MG, Muallem S, Kurtz I . The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO₃⁻ salvage transporter human Na⁺-HCO₃⁻ cotransport isoform 3 . J. Biol. Chem. . 277 . 52 . 50503–9 . December 2002 . 12403779 . 10.1074/jbc.M201862200 . free .