Efrapeptin Explained
Efrapeptins are peptides produced by fungi in the genus Tolypocladium that have antifungal, insecticidal, and mitochondrial ATPase inhibitory activities.[1] They are produced via a biosynthetic pathway similar to, but simpler than, the ciclosporin pathway with nonribosomal peptide synthase (NRPS) and/or polyketide synthase (PKS) being the key elements.[2]
The amino acid sequences of efrapeptins are:
Efrapeptin F: Ac-Pip-Aib-Pip-Aib-Aib-Leu-bAla-Gly-Aib-Aib-Pip-Aib-Ala-Leu-Iva-Unk
Efrapeptin G: Ac-Pip-Aib-Pip-Iva-Aib-Leu-bAla-Gly-Aib-Aib-Pip-Aib-Ala-Leu-Iva-Unk
Aib: 2-methylalanine; Iva: 2-ethylalanine; Unk: does not match to a known amino acid
External links
Notes and References
- 10.1007/BF00992580. 24258490. Identification and directed biosynthesis of efrapeptins in the fungus Tolypocladium geodes gams (Deuteromycotina: Hyphomycetes). Journal of Chemical Ecology. 17. 10. 1953–1962. 1991. Krasnoff. Stuart B. Gupta. Sandeep. 1991JCEco..17.1953K. 6464931.
- Bushley . Kathryn E. . Raja . Rajani . Jaiswal . Pankaj . Cumbie . Jason S. . Nonogaki . Mariko . Boyd . Alexander E. . Owensby . C. Alisha . Knaus . Brian J. . Elser . Justin . Miller . Daniel . Di . Yanming . McPhail . Kerry L. . Spatafora . Joseph W. . Heitman . Joseph . The Genome of Tolypocladium inflatum: Evolution, Organization, and Expression of the Cyclosporin Biosynthetic Gene Cluster . PLOS Genetics . 20 June 2013 . 9 . 6 . e1003496 . 10.1371/journal.pgen.1003496 . 23818858. 3688495 . free .
