Effective circulating volume explained

In hematology, effective circulating volume (ECV) is the volume of arterial blood effectively perfusing tissue.[1] [2] ECV is a dynamic quantity and not a measurable, distinct compartment. This concept is useful for discussion of cardiovascular and renal physiology.

Though ECV normally varies with extracellular fluid (ECF), they become uncoupled in diseases, such as congestive heart failure (CHF) or hepatic cirrhosis. In such cases, decreased ECV may lead to volume depletion responses and edema.

Decreased ECV can stimulate renin secretion or stimulate a sympathetic nervous system response or prostaglandin release (all of which help mediate renal blood flow and glomerular filtration rate among other things).

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Notes and References

  1. Book: Rennke . Helmut G. . Denker . Bradley M. . Renal Pathophysiology: The Essentials . 2007 . Lippincott Williams & Wilkins . 9780781796262 . 46 . registration . Effective circulating volume. . 1 November 2018 . en.
  2. Book: Marik . Paul Ellis . Handbook of Evidence-Based Critical Care . 2001 . Springer Science & Business Media . 9780387951539 . 110 . 1 November 2018 . en.