Sodium calcium edetate explained

Iupac Name:Calcium disodium 2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate
Synonyms:calcium disodium EDTA, edetate calcium disodium, sodium calcium edetate
Tradename:Calcium disodium versenate, others
Pregnancy Us:B
Routes Of Administration:IV, IM
Cas Number:62-33-9
Chebi:4757
Unii:8U5D034955
Class:chelating agent
Atc Prefix:V03
Atc Suffix:AB03
Pubchem:6093170
Drugbank:DB00974
Chemspiderid:5883
Smiles:C(CN(CC(=O)[O-])CC(=O)[O-])N(CC(=O)[O-])CC(=O)[O-].[Na+].[Na+].[Ca+2]
Stdinchi:1S/C10H16N2O8.Ca.2Na/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;;/q;+2;2*+1/p-4
Stdinchikey:SHWNNYZBHZIQQV-UHFFFAOYSA-J
C:10
H:12
Ca:1
N:2
Na:2
O:8

Sodium calcium edetate (sodium calcium EDTA), also known as edetate calcium disodium among other names, is a medication primarily used to treat lead poisoning, including both short-term and long-term lead poisoning. Sodium calcium edetate came into medical use in the United States in 1953.

Chelation agent

Sodium calcium edetate is in the chelating agent family of medication. It is a salt of edetate with two sodium and one calcium atoms.[1] It works by binding to a number of heavy metals, which renders them almost inert and allows them to leave the body in the urine.

Edetate disodium (Endrate) is a different formulation which does not have the same effects.

Medical use

Sodium calcium edetate's primary use is to treat lead poisoning,for which it is an alternative to succimer.It is given by slow injection into a vein or into a muscle.[2]

For lead encephalopathy sodium calcium edetate is typically used together with dimercaprol.It may also be used to treat plutonium poisoning.[3] It does not appear to be useful for poisoning by tetra-ethyl lead.

Side effects

Common side effects include pain at the site of injection.[4] Other side effects may include kidney problems, diarrhea, fever, muscle pains, and low blood pressure.[2] Benefits when needed in pregnancy are likely greater than the risks.[4]

History

Sodium calcium edetate came into medical use in the United States in 1953.[4] It is on the World Health Organization's List of Essential Medicines.[5]

Notes and References

  1. Book: Kasture AV . Pharmaceutical Chemistry . I . 2008 . Pragati Books Pvt. Ltd. . 9788185790121 . 16.11 . en . live . https://web.archive.org/web/20170116152923/https://books.google.ca/books?id=ZkoJsQIhDWkC&pg=SA16-PA11 . 2017-01-16.
  2. Book: WHO Model Formulary 2008 . 2009 . 9789241547659 . Stuart MC, Kouimtzi M, Hill SR . World Health Organization . . 10665/44053 . free . 59, 62, 65.
  3. Book: Flanagan R, Jones A, Maynard RL . Antidotes: Principles and Clinical Applications . 2003 . CRC Press . 9780203485071 . 47 . en . live . https://web.archive.org/web/20170116151507/https://books.google.ca/books?id=Ux0-AAAAIAAJ&pg=PA47 . 2017-01-16.
  4. Web site: Edetate Calcium Disodium . The American Society of Health-System Pharmacists . 8 January 2017 . live . https://web.archive.org/web/20170116204307/https://www.drugs.com/monograph/edetate-calcium-disodium.html . 16 January 2017.
  5. Book: World Health Organization model list of essential medicines: 21st list 2019 . 2019 . . Geneva,CH . 10665/325771 . free . WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO . Organization . World Health .