Eccrine nevus explained

An eccrine nevus is an extremely rare cutaneous condition that, histologically, is characterized by an increase in size or number of eccrine secretory coils.^[1] Hyperhidrosis is the most common symptom. It can present as discoloured nodules, papules, or plaques. Eccrine nevus mostly affects the extremities. Eccrine nevus are diagnosed based of histology. Treatment includes surgical excision or topical medications.

Signs and symptoms

The clinical signs of eccrine nevus might vary, involving a single nodular lesion or a broad patch encompassing the majority of the trunk.^[2] Discolored nodules, papules, and plaques may also be present. The most often reported symptom, though not always present, is hyperhidrosis.^[3] The majority of eccrine nevi are found iin the extremities, with a preference for the forearms.^[4]

Causes

The cause of eccrine nevus is uncertain. The postulated pathogenic variables include congenital abnormalities in embryogenesis, trauma, and stress, although none have been verified.^[5]

Diagnosis

Eccrine nevi are identified histologically, with findings indicating just an increase in the size and/or number of structurally normal eccrine glands. However, there have been cases reported with structural abnormalities, including adenomatous alterations, pseudobasaloid cell nests, and twisted ducts.^[6]

Treatment

The course of treatment for eccrine nevus is determined by the patient's preferences, associated symptoms, and the extent of the lesion. Surgical excision may be the best course of action when the lesion is tiny. Conversely, topical therapies such botulinum toxin or anticholinergic medicines may be used when localized hyperhidrosis coexists with a big skin lesion.^[7]

See also

• Apocrine nevus
• Nevus comedonicus

Further reading

• Va´zquez . María Rodríguez . Fuente . Enrique Gómez de la . Fernández . Jose Gregorio Alvarez . Martín . Francisco Javier Vicente . Estebaranz . Jose Luis López . Moraleda . Fernando Pinedo . Eccrine Naevus: Case Report and Literature Review . Acta Dermato-Venereologica . Medical Journals Sweden AB . 82 . 2 . 2002-03-01 . 0001-5555 . 10.1080/00015550252948310 . 154–156 . none. free .
• Dua . Janet . Grabczynska . Sophie . Eccrine Nevus Affecting the Forearm of an 11-Year-Old Girl Successfully Controlled with Topical Glycopyrrolate . Pediatric Dermatology . Wiley . 31 . 5 . 2013-03-28 . 0736-8046 . 10.1111/pde.12127 . 611–612 . 23534977 . none.

Notes and References

1. Freedberg, et al. (2003). Fitzpatrick's Dermatology in General Medicine. (6th ed.). McGraw-Hill. .
2. Salama . Hania . Shwayder . Tor . Eccrine Nevus Presenting as a Hypopigmented Patch . Pediatric Dermatology . Wiley . 25 . 6 . 2008 . 0736-8046 . 10.1111/j.1525-1470.2008.00719.x . 613–615. 19067865 .
3. Bidari-Zerehpoosh . Farahnaz . Sabeti . Shahram . Arman . Farid . Shakeri . Hania . Eccrine Nevus Presenting with Umbilical Discharge: A Case Report and Review of the Literature . Case Reports in Dermatological Medicine . Hindawi Limited . 2017 . 2017 . 2090-6463 . 10.1155/2017/9761843 . free . 1–3. 28421149 . 5379080 .
4. Lee . Hanjae . Cho . Soyun . Eccrine Nevus on the Neck: A Case Report and Review of the Literature . Annals of Dermatology . Korean Dermatological Association and The Korean Society for Investigative Dermatology . 33 . 5 . 2021 . 456–458 . 1013-9087 . 10.5021/ad.2021.33.5.456 . 34616127 . 8460470 .
5. Tempark . T. . Shwayder . T. . Mucinous eccrine naevus: case report and review of the literature . Clinical and Experimental Dermatology . Oxford University Press (OUP) . 38 . 1 . 2012-12-18 . 0307-6938 . 10.1111/ced.12034 . 1–6. 23252751 .
6. Kang . Min Ju . Yu . Dong Soo . Kim . Jin Wou . A Case of Eccrine Nevus . Annals of Dermatology . Korean Dermatological Association and The Korean Society for Investigative Dermatology . 20 . 1 . 2008 . 29–31 . 1013-9087 . 10.5021/ad.2008.20.1.29 . 27303155 . 4904045 .
7. Christopher Kawaoka . John . Gray . Jennifer . Schappell . Deborah . Robinson-Bostom . Leslie . Eccrine nevus . Journal of the American Academy of Dermatology . Elsevier BV . 51 . 2 . 2004 . 0190-9622 . 10.1016/j.jaad.2003.12.030 . 301–304. 15280853 .