| Official Name: | Eastern Slovakia |
| Native Name: | Východné Slovensko |
| Settlement Type: | Region |
| Area Total Km2: | 15728.4 |
| Area Footnotes: | [1] |
| Population Total: | 1625436 |
| Population Footnotes: | [2] |
| Population Density Km2: | auto |
| Demographics Type2: | GDP |
| Demographics2 Footnotes: | [3] |
| Demographics2 Title1: | Total |
| Demographics2 Info1: | €21.208 billion (2021) |
| Blank Name Sec1: | NUTS code |
| Blank Info Sec1: | SK04 |
| Blank1 Name Sec2: | HDI (2019) |
| Blank1 Info Sec2: | 0.824[4] · 4th |
Eastern Slovakia (Slovak: Východné Slovensko) is one of the four NUTS-2 Regions of Slovakia. It was created at the same time as were the Košice and Prešov regions. Eastern Slovakia is the least developed of the four NUTS-2 regions of Slovakia, with its GDP per capita being 54% of the European Union average (€16,300 per year).