EIF4A3 explained

Eukaryotic initiation factor 4A-III is a protein that in humans is encoded by the EIF4A3 gene.^{[1] [2] [3]}

Function

This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a nuclear matrix protein. Its amino acid sequence is highly similar to the amino acid sequences of the translation initiation factors eIF4A-I and eIF4A-II, two other members of the DEAD box protein family.

Further reading

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• Li Q . Eukaryotic Translation Initiation Factor 4AIII (eIF4AIII) Is Functionally Distinct from eIF4AI and eIF4AII . Mol. Cell. Biol. . 19 . 11 . 7336–46 . 1999 . 10523622 . 10.1128/mcb.19.11.7336. 84727 . Imataka H . Morino S . Rogers Jr . GW . Richter-Cook . NJ . Merrick . WC . Sonenberg . N .
• Jurica MS . Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis . RNA . 8 . 4 . 426–39 . 2002 . 11991638 . 10.1017/S1355838202021088 . 1370266 . Licklider LJ . Gygi SR . Grigorieff . Nikolaus . Moore . Melissa J. .
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• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . Feingold EA . Grouse LH . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Palacios IM, Gatfield D, St Johnston D, Izaurralde E . An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay . Nature . 427 . 6976 . 753–7 . 2004 . 14973490 . 10.1038/nature02351 . 2004Natur.427..753P . 4400243 .
• Ferraiuolo MA . A nuclear translation-like factor eIF4AIII is recruited to the mRNA during splicing and functions in nonsense-mediated decay . Proc. Natl. Acad. Sci. U.S.A. . 101 . 12 . 4118–23 . 2004 . 15024115 . 10.1073/pnas.0400933101 . 384704 . Lee CS . Ler LW . Hsu . J. L. . Costa-Mattioli . M. . Luo . M.-J. . Reed . R. . Sonenberg . N. . 2004PNAS..101.4118F . free .
• Shibuya T, Tange TØ, Sonenberg N, Moore MJ . eIF4AIII binds spliced mRNA in the exon junction complex and is essential for nonsense-mediated decay . Nat. Struct. Mol. Biol. . 11 . 4 . 346–51 . 2004 . 15034551 . 10.1038/nsmb750 . 30171314 .
• Jin J . Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization . Curr. Biol. . 14 . 16 . 1436–50 . 2004 . 15324660 . 10.1016/j.cub.2004.07.051 . Smith FD . Stark C . Wells . Clark D. . Fawcett . James P. . Kulkarni . Sarang . Metalnikov . Pavel . O'Donnell . Paul . Taylor . Paul . 2371325 . free . 2004CBio...14.1436J .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . Wagner L . Feingold EA . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Andersen JS . Nucleolar proteome dynamics . Nature . 433 . 7021 . 77–83 . 2005 . 15635413 . 10.1038/nature03207 . Lam YW . Leung AK . Ong . Shao-En . Lyon . Carol E. . Lamond . Angus I. . Mann . Matthias . 2005Natur.433...77A . 4344740 .
• Xia Q . Proteomics-based identification of DEAD-box protein 48 as a novel autoantigen, a prospective serum marker for pancreatic cancer . Biochem. Biophys. Res. Commun. . 330 . 2 . 526–32 . 2005 . 15796914 . 10.1016/j.bbrc.2005.02.181 . Kong XT . Zhang GA . Hou . Xiao-Jin . Qiang . Hua . Zhong . Ren-Qian .
• Ballut L . The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity . Nat. Struct. Mol. Biol. . 12 . 10 . 861–9 . 2005 . 16170325 . 10.1038/nsmb990 . Marchadier B . Baguet A . Tomasetto . Catherine . Séraphin . Bertrand . Le Hir . Hervé . 1359792 .
• Rual JF . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . Venkatesan K . Hao T . Hirozane-Kishikawa . Tomoko . Dricot . Amélie . Li . Ning . Berriz . Gabriel F. . Gibbons . Francis D. . Dreze . Matija . 2005Natur.437.1173R . 4427026 .
• Gehring NH . Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements . Mol. Cell . 20 . 1 . 65–75 . 2005 . 16209946 . 10.1016/j.molcel.2005.08.012 . Kunz JB . Neu-Yilik G . Breit . Stephen . Viegas . Marcelo H. . Hentze . Matthias W. . Kulozik . Andreas E. . free .
• Andersen CB . Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA . Science . 313 . 5795 . 1968–72 . 2006 . 16931718 . 10.1126/science.1131981 . Ballut L . Johansen JS . Chamieh . H . Nielsen . KH . Oliveira . CL . Pedersen . JS . Séraphin . B . Le Hir . H . 2006Sci...313.1968A . 26409491 .
• You KT . Selective Translational Repression of Truncated Proteins from Frameshift Mutation-Derived mRNAs in Tumors . PLOS Biol. . 5 . 5 . e109 . 2007 . 17456004 . 10.1371/journal.pbio.0050109 . 1854916 . Li LS . Kim NG . Kang . Hyun Ju . Koh . Kwi Hye . Chwae . Yong-Joon . Kim . Kyoung Mi . Kim . Yoon Ki . Park . Sung Mi . free .
• Zhang Z, Krainer AR . Splicing remodels messenger ribonucleoprotein architecture via eIF4A3-dependent and -independent recruitment of exon junction complex components . Proc. Natl. Acad. Sci. U.S.A. . 104 . 28 . 11574–9 . 2007 . 17606899 . 10.1073/pnas.0704946104 . 1913901 . 2007PNAS..10411574Z . free .

Notes and References

1. Holzmann K, Gerner C, Poltl A, Schafer R, Obrist P, Ensinger C, Grimm R, Sauermann G . A human common nuclear matrix protein homologous to eukaryotic translation initiation factor 4A . Biochem Biophys Res Commun . 267 . 1 . 339–44 . Feb 2000 . 10623621 . 10.1006/bbrc.1999.1973 .
2. Chan CC, Dostie J, Diem MD, Feng W, Mann M, Rappsilber J, Dreyfuss G . eIF4A3 is a novel component of the exon junction complex . RNA . 10 . 2 . 200–9 . Jan 2004 . 14730019 . 1370532 . 10.1261/rna.5230104 .
3. Web site: Entrez Gene: EIF4A3 eukaryotic translation initiation factor 4A, isoform 3.