Dynamin superfamily explained

Symbol:	DSP
Dynamin superfamily
Interpro:	IPR022812

Dynamin Superfamily Protein (DSP) is a protein superfamily includes classical dynamins, GBPs, Mx proteins, OPA1, mitofusins in Eukaryote, and bacterial dynamin-like proteins (BDLPs) in Prokaryote.^[1] DSPs mediate eukaryotic membrane fusion and fission necessary for endocytosis, organelle biogenesis and maintenance, Mitochondrial fusion and fission, as well as for prokaryotic cytokinesis.^[2]

Structure

All DSPs have two common domains: a GTPase domain and an elongated α-helical bundle domain.^[2]

Notes and References

1. Henley JR, Cao H, McNiven MA . Participation of dynamin in the biogenesis of cytoplasmic vesicles . FASEB Journal . 13 Suppl 2 . 9002 . S243-7 . December 1999 . 10619136 . 10.1096/fasebj.13.9002.S243 . free . 24401725 .
2. Jimah . JR . Hinshaw . JE . Structural Insights into the Mechanism of Dynamin Superfamily Proteins. . Trends in Cell Biology . March 2019 . 29 . 3 . 257–273 . 10.1016/j.tcb.2018.11.003 . 30527453. 9623552 . 54478789 .