Dual-specificity kinase explained
| Dual-specificity kinase |
| Ec Number: | 2.7.12.1 |
| Cas Number: | 134549-83-0 |
In biochemistry, a dual-specificity kinase is a kinase that can act as both tyrosine kinase and serine/threonine kinase.
MEKs, involved in MAP pathways, are principal examples of dual-specificity kinases. Other common examples include:
The systematic name of this enzyme class is ATP:protein phosphotransferase (Ser/Thr- and Tyr-phosphorylating).
References
- Dhanasekaran N, Premkumar Reddy E . 1998 . Signaling by dual specificity kinases . Oncogene . 17 . 11 Reviews . 1447–1455 . 9779990 . 10.1038/sj.onc.1202251. free .
- Ali N, Halfter U, Chua NH . 1994 . Cloning and biochemical characterization of a plant protein kinase that phosphorylates serine, threonine, and tyrosine . J. Biol. Chem. . 269 . 31626–9 . 7527390 . 50 .
- Lauze E, Stoelcker B, Luca FC, Weiss E, Schutz AR, Winey M . 1995 . Yeast spindle pole body duplication gene MPS1 encodes an essential dual specificity protein kinase . EMBO J. . 14 . 1655–63 . 7737118 . 8 . 398258 .
- Menegay HJ, Myers MP, Moeslein FM, Landreth GE . Biochemical characterization and localization of the dual specificity kinase CLK1 . J. Cell Sci. . 113 . 3241–53 . 10954422 .
- Cleghon V . 2003 . dDYRK2: a novel dual-specificity tyrosine-phosphorylation-regulated kinase in Drosophila . Biochem. J. . 374 . 381–91 . 12786602 . 10.1042/BJ20030500 . Sibbet . G . Kinstrie . R . Cleghon . T . Rylatt . M . Morrison . DK . Cleghon . V . Pt 2 . 1223608 .
