Dual amylin and calcitonin receptor agonists explained

Dual amylin and calcitonin receptor agonists (DACRAs) are a class of drugs that act as agonists at the amylin receptor and calcitonin receptor that are under development as therapies for obesity and type 2 diabetes. Examples are cagrilintide and the KBP family derived from salmon calcitonin,[1] including KBP‐042,[2] KBP-066A,[3] KBP-089,[4] and KBP-336.[5]

Notes and References

  1. Larsen . A. T. . Mohamed . K. E. . Sonne . N. . Bredtoft . E. . Andersen . F. . Karsdal . M. A. . Henriksen . K. . Does receptor balance matter? - Comparing the efficacies of the dual amylin and calcitonin receptor agonists cagrilintide and KBP-336 on metabolic parameters in preclinical models . Biomedicine & Pharmacotherapy . December 2022 . 156 . 113842 . 10.1016/j.biopha.2022.113842 . 36242844 . 1950-6007. free .
  2. Henriksen . Kim . Broekhuizen . Karen . de Boon . Wadim M. I. . Karsdal . Morten A. . Bihlet . Asger R. . Christiansen . Claus . Dillingh . Marlous R. . de Kam . Marieke . Kumar . Raj . Burggraaf . Jacobus . Kamerling . Ingrid M. C. . Safety, tolerability and pharmacokinetic characterisation of DACRA KBP‐042 in healthy male subjects . British Journal of Clinical Pharmacology . December 2021 . 87 . 12 . 4786–4796 . 10.1111/bcp.14921 . 235093884 . en . 0306-5251. free .
  3. Andreassen . K. V. . Larsen . A. T. . Sonne . N. . Mohamed . K. E. . Karsdal . M. A. . Henriksen . K. . KBP-066A, a long-acting dual amylin and calcitonin receptor agonist, induces weight loss and improves glycemic control in obese and diabetic rats . Molecular Metabolism . 1 November 2021 . 53 . 101282 . 10.1016/j.molmet.2021.101282 . 34214708 . 8313742 . 2212-8778. free .
  4. Larsen . Anna Thorsø . Gydesen . Sofie . Sonne . Nina . Karsdal . Morten Asser . Henriksen . Kim . The dual amylin and calcitonin receptor agonist KBP-089 and the GLP-1 receptor agonist liraglutide act complimentarily on body weight reduction and metabolic profile . BMC Endocrine Disorders . 7 January 2021 . 21 . 1 . 10 . 10.1186/s12902-020-00678-2 . 33413317 . 1472-6823. free . 7791885 .
  5. Melander . Simone A. . Larsen . Anna T. . Elhady Mohamed . Khaled . Karsdal . Morten A. . Henriksen . Kim . 840-P: Dual Amylin and Calcitonin Receptor Agonist Treatment Improves Blood Pressure and Glucose Control in ZSF1 Rats . Diabetes . 20 June 2023 . 72 . Supplement_1 . 10.2337/db23-840-P . 259415731 .

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Dual amylin and calcitonin receptor agonists".

Except where otherwise indicated, Everything.Explained.Today is © Copyright 2009-2024, A B Cryer, All Rights Reserved. Cookie policy.