L-Dopaquinone Explained

-Dopaquinone also known as o-dopaquinone is a metabolite of L-DOPA (L-dihydroxyphenylalanine) and a precursor of melanin.[1] [2]

Biosynthesis of melanin occurs in melanocytes, where tyrosine is converted into DOPA and then dopaquinone, which goes on to be formed into pheomelanin or eumelanin.[3]

Notes and References

  1. Ito S, Wakamatsu K . Chemistry of mixed melanogenesis – pivotal roles of dopaquinone . Photochem. Photobiol. . 84 . 3 . 582–92 . 2008 . 18435614 . 10.1111/j.1751-1097.2007.00238.x .
  2. Hearing VJ . Determination of melanin synthetic pathways . J. Invest. Dermatol. . 131 . E1 . E8–E11 . 2011 . 22094404 . 10.1038/skinbio.2011.4 . 6944209 . free .
  3. Web site: Schlessinger . Daniel I. . Schlessinger . Joel . Biochemistry, Melanin . January 2020 . 29083759 . 22 May 2020 . StatPearls Publishing.

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