Monoamine-depleting agent explained

Monoamine-depleting agents are a group of drugs which reversibly deplete one or more monoamine neurotransmitters.[1] [2] One mechanism by which these agents act is by inhibiting reuptake by the vesicular monoamine transporters, VMAT1 and VMAT2.[3] Examples of monoamine-depleting agents include deutetrabenazine, oxypertine, reserpine, tetrabenazine, and valbenazine.

Notes and References

  1. Carlsson A . Monoamine-depleting drugs . Pharmacol Ther B . 1 . 3 . 393–400 . 1975 . 772709 . 10.1016/0306-039x(75)90045-8 .
  2. Vijayakumar D, Jankovic J . Drug-Induced Dyskinesia, Part 2: Treatment of Tardive Dyskinesia . Drugs . 76 . 7 . 779–87 . May 2016 . 27091214 . 10.1007/s40265-016-0568-1 . 13570794 .
  3. Guay DR . Tetrabenazine, a monoamine-depleting drug used in the treatment of hyperkinetic movement disorders . Am J Geriatr Pharmacother . 8 . 4 . 331–73 . August 2010 . 20869622 . 10.1016/j.amjopharm.2010.08.006 .

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