Dolichyl-phosphate beta-glucosyltransferase explained

dolichyl-phosphate beta-glucosyltransferase
Ec Number:	2.4.1.117
Cas Number:	71061-42-2
Go Code:	0004581

In enzymology, a dolichyl-phosphate beta-glucosyltransferase is an enzyme that catalyzes the chemical reaction

UDP-glucose + dolichyl phosphate

\rightleftharpoons UDP + dolichyl beta-D-glucosyl phosphate

Thus, the two substrates of this enzyme are UDP-glucose and dolichyl phosphate, whereas its two products are UDP and dolichyl beta-D-glucosyl phosphate.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-glucose:dolichyl-phosphate beta-D-glucosyltransferase. Other names in common use include polyprenyl phosphate:UDP-D-glucose glucosyltransferase, UDP-glucose dolichyl-phosphate glucosyltransferase, uridine diphosphoglucose-dolichol glucosyltransferase, UDP-glucose:dolichol phosphate glucosyltransferase, UDP-glucose:dolicholphosphoryl glucosyltransferase, UDP-glucose:dolichyl monophosphate glucosyltransferase, and UDP-glucose:dolichyl phosphate glucosyltransferase. This enzyme participates in n-glycan biosynthesis.

References

• Behrens NH, Leloir LF . 1970 . Dolichol monophosphate glucose: an intermediate in glucose transfer in liver . Proc. Natl. Acad. Sci. U.S.A. . 66 . 153 - 9 . 5273893 . 10.1073/pnas.66.1.153 . 1 . 286101 . free .
• Roger W. Jeanloz . Herscovics A, Bugge B, Jeanloz RW . 1977 . Glucosyltransferase activity in calf pancreas microsomes. Formation of dolichyl D[14C]glucosyl phosphate and 14C-labeled lipid-linked oligosaccharides from UDP-D-[14C]glucose . J. Biol. Chem. . 252 . 2271 - 7 . 849929 . 7 . 10.1016/S0021-9258(17)40550-3 . free .
• Villemez CL, Carlo PL . 1979 . Properties of a soluble polyprenyl phosphate: UDP-D-glucose glucosyltransferase . J. Biol. Chem. . 254 . 4814 - 9 . 438216 . 11 . 10.1016/S0021-9258(17)30085-6 . free .