Dolichyl-phosphate alpha-N-acetylglucosaminyltransferase explained
| dolichyl-phosphate alpha-N-acetylglucosaminyltransferase |
| Ec Number: | 2.4.1.153 |
| Cas Number: | 63363-73-5 |
| Go Code: | 0004166 |
In enzymology, a dolichyl-phosphate alpha-N-acetylglucosaminyltransferase is an enzyme that catalyzes the chemical reaction
UDP-N-acetyl-D-glucosamine + dolichyl phosphate
UDP + dolichyl N-acetyl-alpha-D-glucosaminyl phosphate
Thus, the two substrates of this enzyme are UDP-N-acetyl-D-glucosamine and dolichyl phosphate, whereas its two products are UDP and dolichyl N-acetyl-alpha-D-glucosaminyl phosphate.
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-N-acetyl-D-glucosamine:dolichyl-phosphate alpha-N-acetyl-D-glucosaminyltransferase. Other names in common use include uridine diphosphoacetylglucosamine-dolichol phosphate, acetylglucosaminyltransferase, dolichyl phosphate acetylglucosaminyltransferase, dolichyl phosphate N-acetylglucosaminyltransferase, UDP-N-acetylglucosamine-dolichol phosphate, and N-acetylglucosaminyltransferase.
References
- Leloir LF, Staneloni RJ, Carminatti H, Behrens NH . 1973 . The biosynthesis of a N,N'-diacetylchitobiose containing lipid by liver microsomes. A probable dolichol pyrophosphate derivative . Biochem. Biophys. Res. Commun. . 52 . 1285 - 92 . 4717748 . 10.1016/0006-291X(73)90640-2 . 4 . 11336/141022 . free .
- Molnar J, Chao H, Ikehara Y . 1971 . Phosphoryl-N-acetylglucosamine transfer to a lipid acceptor of liver microsomal preparations . Biochim. Biophys. Acta . 239 . 401 - 10 . 5113503 . 3 . 10.1016/0005-2760(71)90033-6.
- Tetas M, Chao H, Molnar J . 1970 . Incorporation of carbohydrates into endogenous acceptors of liver microsomal fractions . Arch. Biochem. Biophys. . 138 . 135 - 46 . 4315690 . 10.1016/0003-9861(70)90292-4 . 1 .
- Warren CD, Jeanloz RW. Roger W. Jeanloz . 1974 . Chemical synthesis of P1-2-acetamido-2-deoxy-alpha-D-glucopyranosyl P2-dolichyl pyrophosphate . Carbohydr. Res. . 37 . 252 - 60 . 4371972 . 10.1016/S0008-6215(00)87080-9 . 1 .
