Dolichyl-phosphate-mannose-protein mannosyltransferase explained

dolichyl-phosphate-mannose-protein mannosyltransferase
Ec Number:	2.4.1.109
Cas Number:	74315-99-4
Go Code:	0004169

In enzymology, a dolichyl-phosphate-mannose-protein mannosyltransferase is an enzyme that catalyzes the chemical reaction

dolichyl phosphate D-mannose + protein

\rightleftharpoons dolichyl phosphate + O-D-mannosylprotein

Thus, the two substrates of this enzyme are dolichyl phosphate D-mannose and protein, whereas its two products are dolichyl phosphate and O-D-mannosylprotein.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is dolichyl-phosphate-D-mannose:protein O-D-mannosyltransferase. Other names in common use include dolichol phosphomannose-protein mannosyltransferase, and protein O-D-mannosyltransferase. A human gene that codes for this enzyme is POMT1.

References

• Babczinski P, Haselbeck A, Tanner W . 1980 . Yeast mannosyl transferases requiring dolichyl phosphate and dolichyl phosphate mannose as substrate. Partial purification and characterization of the solubilized enzyme . Eur. J. Biochem. . 105 . 509 - 15 . 6989607 . 10.1111/j.1432-1033.1980.tb04526.x . 3 .
• Palamarczyk G, Lehle L, Mankowski T, Chojnacki T, Tanner W . 1980 . Specificity of solubilized yeast glycosyl transferases for polyprenyl derivatives . Eur. J. Biochem. . 105 . 517 - 23 . 6445267 . 10.1111/j.1432-1033.1980.tb04527.x . 3 . free .