Dolichyl-phosphatase explained

dolichyl-phosphatase
Ec Number:	3.1.3.51
Cas Number:	72994-50-4
Go Code:	0047873

The enzyme dolichyl-phosphatase (EC 3.1.3.51) catalyzes the reaction

dolichyl phosphate + H₂O

\rightleftharpoons dolichol + phosphate

This enzyme belongs to the family of hydrolases, to be specific, those acting on phosphoric monoester bonds. The systematic name is dolichyl-phosphate phosphohydrolase. Other names in common use include dolichol phosphate phosphatase, dolichol phosphatase, dolichol monophosphatase, dolichyl monophosphate phosphatase, dolichyl phosphate phosphatase, polyisoprenyl phosphate phosphatase, polyprenylphosphate phosphatase, and Dol-P phosphatase. This enzyme participates in N-linked-glycan biosynthesis.

References

• Adrian GS, Keenan RW . 1979 . A dolichyl phosphate-cleaving acid phosphatase from Tetrahymena pyriformis . Biochim. Biophys. Acta . 575 . 431 - 8 . 229909 . 3 . 10.1016/0005-2760(79)90112-7.
• Rip JW, Rupar CA, Chaudhary N, Carroll KK . 1981 . Localization of a dolichyl phosphate phosphatase in plasma membranes of rat liver . J. Biol. Chem. . 256 . 1929 - 34 . 6257694 . 4 .
• Wedgwood JF, Strominger JL . 1980 . Enzymatic activities in cultured human lymphocytes that dephosphorylate dolichyl pyrophosphate and dolichyl phosphate . J. Biol. Chem. . 255 . 1120 - 3 . 6243292 . 3 .