Doisynoestrol Explained

Doisynoestrol (brand names Fenocyclin, Surestrine, Surestryl; former developmental code name RS-2874), also known as fenocycline, as well as cis-bisdehydrodoisynolic acid 7-methyl ether (BDDA ME), is a synthetic nonsteroidal estrogen of the doisynolic acid group that is no longer marketed.[1] [2] It is a methyl ether of bisdehydrodoisynolic acid. Doisynoestrol was described in the literature in 1945. It has about 0.02% of the relative binding affinity of estradiol for the estrogen receptor.[3]

See also

Notes and References

  1. Book: Elks J . The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. 14 November 2014. Springer. 978-1-4757-2085-3. 465–.
  2. Herbai G . Separation of growth inhibiting potency from oestrogenicity in different weak oestrogenic drugs of various chemical structures . Acta Endocrinologica . 68 . 2 . 249–63 . October 1971 . 5171465 . 10.1530/acta.0.0680249 .
  3. Blair RM, Fang H, Branham WS, Hass BS, Dial SL, Moland CL, Tong W, Shi L, Perkins R, Sheehan DM . The estrogen receptor relative binding affinities of 188 natural and xenochemicals: structural diversity of ligands . Toxicol Sci . 54 . 1 . 138–53 . March 2000 . 10746941 . 10.1093/toxsci/54.1.138 . free .

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