| District | Capital | Area (km2) | Population | Province/Comarca |
|---|
| Puerto Almirante | | 21,841 | Bocas del Toro Province |
| Bocas del Toro | Bocas del Toro | 433.2 | 21,396 |
| Changuinola | Changuinola | 3,995 | 98,310 |
| Chiriquí Grande | Chiriquí Grande | 210 | 14,533 |
| Alanje | Alanje | 447 | 15,497 | Chiriquí Province |
| Barú | Puerto Armuelles | 589 | 60,551 |
| Boquerón | Boquerón | 282 | 12,275 |
| Boquete | Bajo Boquete | 489 | 16,943 |
| Bugaba | La Concepción | 884 | 68,570 |
| David | David | 870 | 14,858 |
| Dolega | San Francisco de Dolega | 249 | 17,243 |
| Gualaca | Gualaca | 626 | 8,348 |
| Remedios | Remedios | 268 | 3,349 |
| Renacimiento | Río Sereno | 428 | 18,257 |
| San Félix | Las Lajas | 220 | 5,276 |
| San Lorenzo | Horconcitos | 738 | 6,498 |
| Tolé | Tolé | 488 | 11,563 |
| Tierras Altas | Volcán | | |
| Aguadulce | Aguadulce | 466 | 39,290 | Coclé Province |
| Antón | Antón | 749 | 44,039 |
| La Pintada | La Pintada | 1,030 | 23,202 |
| Natá | Natá | 608 | 17,811 |
| Olá | Olá | 381 | 5,671 |
| Penonomé | Penonomé | 1,708.6 | 85,737 |
| Colón | Colón City | 1,180 | 253,266 | Colón Province |
| Chagres | Nuevo Chagres | 445 | 11,342 |
| Donoso | Miguel de la Borda | 1,826 | 14,798 |
| Omar Torrijos Herrera | Coclesito | 198.6 | 2,248 |
| Portobelo | Portobelo | 397 | 10,581 |
| Santa Isabel | Palenque | 727 | 3,973 |
| Chepigana | La Palma | 4,625.1 | 30,110 | Darién Province |
| Pinogana | El Real de Santa María | 4,901 | 26,160 |
| Santa Fe | Santa Fe | 2,683.6 | 16,089 |
| Cémaco | Unión Chocó | 3,097.5 | 7,715 | Emberá-Wounaan Comarca |
| Sambú | Puerto Indio | 1,296.4 | 2,286 |
| Guna Yala | Gaigirgordub | 2,358.2 | 33,109 | Guna Yala Comarca |
| Chitré | Chitré | 91 | 42,467 | Herrera Province |
| Las Minas | Las Minas | 437 | 7,945 |
| Los Pozos | Los Pozos | 383 | 7,827 |
| Ocú | Ocú | 625 | 15,936 |
| Parita | Parita | 364 | 8,827 |
| Pesé | Pesé | 284 | 12,471 |
| Santa María | Santa María | 158 | 6,992 |
| Guararé | Guararé | 216 | 11,144 | Los Santos Province |
| Las Tablas | Las Tablas | 711 | 29,531 |
| Los Santos | La Villa de los Santos | 429 | 27,323 |
| Macaracas | Macaracas | 504 | 9,285 |
| Pedasí | Pedasí | 378.3 | 4,696 |
| Pocrí | Pocrí | 280 | 3,484 |
| Tonosí | Tonosí | 1,294 | 10,094 |
| Naso Tjër Di | Sieyic | 1,606.3 | | Naso Tjër Di Comarca |
| Besikó | Soloy | 752.2 | 23,532 | Ngäbe-Buglé Comarca |
| Jirondai | Samboa | | 24,150 |
| Kankintú | Bisira | 2,422.1 | 33,121 |
| Kusapín | Kusapín | 1,693.2 | 20,909 |
| Mironó | Hato Pilón | 343.1 | 15,010 |
| Müna | Chichica | 796.4 | 36,075 |
| Nole Duima | Cerro Iglesias | 185.1 | 14,928 |
| Ñürüm | Buenos Aires | 574.7 | 13,172 |
| Santa Catalina o Calovébora | Santa Catalina o Calovébora | | 7,821 |
| Balboa | San Miguel | 333 | 3,332 | Panamá Province |
| Chepo | Chepo | 4,937 | 59,382 |
| Chimán | Chimán | 1,046 | 3,531 |
| Panamá | Panama City | 2,031 | 1,183,333 |
| San Miguelito | San Miguelito | 50.1 | 375,409 |
| Taboga | Taboga | 12.1 | 1,387 |
| Arraiján | Arraiján | 418 | 296,188 | Panamá Oeste Province |
| Capira | Capira | 978 | 47,244 |
| Chame | Chame | 377 | 31,373 |
| La Chorrera | La Chorrera | 770 | 199,708 |
| San Carlos | San Carlos | 338 | 24,001 |
| Atalaya | Atalaya | 156 | 11,321 | Veraguas Province |
| Calobre | Calobre | 806 | 12,159 |
| Cañazas | Cañazas | 789 | 18,022 |
| La Mesa | La Mesa | 511 | 12,052 |
| Las Palmas | Las Palmas | 1,015 | 18,493 |
| Mariato | Mariato | 1,381 | 5,564 |
| Montijo | Montijo | 780 | 7,060 |
| Río de Jesús | Río de Jesús | 302 | 5,501 |
| San Francisco | San Francisco | 437 | 10,536 |
| Santa Fe | Santa Fe | 1,920 | 17,341 |
| Santiago | Santiago de Veraguas | 971 | 129,821 |
| Soná | Soná | 1,519 | 29,774 | |
