| diphthine synthase | |
| Ec Number: | 2.1.1.98 |
| Cas Number: | 114514-25-9 |
| Go Code: | 0004164 |
In enzymology, a diphthine synthase is an enzyme that catalyzes the chemical reaction
S-adenosyl-L-methionine + 2-(3-carboxy-3-aminopropyl)-L-histidine
\rightleftharpoons
Thus, the two substrates of this enzyme are S-adenosyl methionine and 2-(3-carboxy-3-aminopropyl)-L-histidine, whereas its two products are S-adenosylhomocysteine and 2-[3-carboxy-3-(methylammonio)propyl]-L-histidine.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:2-(3-carboxy-3-aminopropyl)-L-histidine methyltransferase. Other names in common use include S-adenosyl-L-methionine:elongation factor 2 methyltransferase, and diphthine methyltransferase.
As of late 2007, 84 structures have been solved for this class of enzymes, with PDB accession codes,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, and .