Diphenylpyraline Explained

Diphenylpyraline (DPP; sold as Allergen, Arbid, Belfene, Diafen, Hispril, Histyn, Lergobine, Lyssipol, Mepiben, Neargal) is a first-generation antihistamine with anticholinergic effects of the diphenylpiperidine class.^{[1] [2] [3]} It is marketed in Europe for the treatment of allergies.^[4] DPP has also been found to act as a dopamine reuptake inhibitor and produces hyperactivity in rodents.^[5] It has been shown to be useful in the treatment of Parkinsonism.^[6]

Notes and References

1. Book: Swiss Pharmaceutical Society . Index Nominum 2000: International Drug Directory (Book with CD-ROM) . Medpharm Scientific Publishers . Boca Raton . 2000 . 3-88763-075-0 .
2. Puhakka H, Rantanen T, Virolainen E . Diphenylpyraline (Lergobine) in the treatment of patients suffering from allergic and vasomotor rhinitis . J Int Med Res . 5 . 1 . 37–41 . 1977 . 14039. 10.1177/030006057700500106 . 19330175 .
3. Kubo N, Shirakawa O, Kuno T, Tanaka C . Antimuscarinic effects of antihistamines: quantitative evaluation by receptor-binding assay . Japanese Journal of Pharmacology . 43 . 3 . 277–82 . March 1987 . 2884340 . 10.1254/jjp.43.277. free .
4. Book: Hruby VJ, Vardanyan R, Vardanyan R . Antihistamine Drugs . Synthesis of Essential Drugs . Elsevier . Amsterdam . 2006 . 0-444-52166-6 . https://books.google.com/books?id=Jjc7KYWZdOYC&q=Diphenylpyraline&pg=PA230.
5. Lapa G, Mathews T, Harp J, Budygin E, Jones S . Diphenylpyraline, a histamine H1 receptor antagonist, has psychostimulant properties . Eur J Pharmacol . 506 . 3 . 237–40 . 2005 . 15627433 . 10.1016/j.ejphar.2004.11.017.
6. Ohno T, Kobayashi S, Hayashi M, Sakurai M, Kanazawa I . Diphenylpyraline-responsive parkinsonism in cerebrotendinous xanthomatosis: long-term follow up of three patients . J Neurol Sci . 182 . 2 . 95–7 . 2001 . 11137513 . 10.1016/S0022-510X(00)00441-X. 35946097 .