Diphenylbutylpiperidine Explained

Diphenylbutylpiperidines are a class of typical antipsychotic drugs which were all synthesized, developed, and marketed by Janssen Pharmaceutica.^{[1] [2]}

They include:

• Clopimozide (R-29,764)
• Fluspirilene (Redeptin)
• Penfluridol (Semap, Micefal, Longoperidol)
• Pimozide (Orap)

A closely related antipsychotic, amperozide, has an additional nitrogen atom in the heterocyclic ring and is classified as a diphenylbutylpiperazine.^[3]

Notes and References

1. Galizzi JP, Fosset M, Romey G, Laduron P, Lazdunski M . Neuroleptics of the diphenylbutylpiperidine series are potent calcium channel inhibitors . Proceedings of the National Academy of Sciences of the United States of America . 83 . 19 . 7513–7 . October 1986 . 2429309 . 386749 . 10.1073/pnas.83.19.7513. free . 1986PNAS...83.7513G .
2. Qar J, Galizzi JP, Fosset M, Lazdunski M . Receptors for diphenylbutylpiperidine neuroleptics in brain, cardiac, and smooth muscle membranes. Relationship with receptors for 1,4-dihydropyridines and phenylalkylamines and with Ca2+ channel blockade . European Journal of Pharmacology . 141 . 2 . 261–8 . September 1987 . 2445589 . 10.1016/0014-2999(87)90271-8.
3. Book: 10.1016/S0378-6080(05)80189-8 . Antipsychotic drugs . Side Effects of Drugs Annual . 1993 . Figueras . Albert . Capellà . Dolors . 17 . 49–71 . 978-0-444-82005-1 .