Dipeptidase E Explained

Dipeptidase E
Ec Number:	3.4.13.21

Uniprot:	P36936
Symbol:	PepE
Organism:	Salmonella typhimurium

Dipeptidase E (aspartyl dipeptidase, peptidase E, PepE gene product (Salmonella typhimurium)) is an enzyme.^{[1] [2]} This enzyme catalyses the following chemical reaction

Dipeptidase E catalyses the hydrolysis of dipeptides Asp!Xaa. It does not act on peptides with N-terminal Glu, Asn or Gln, nor does it cleave isoaspartyl peptides

A free carboxy group is not absolutely required in the substrate.

Notes and References

1. Håkansson K, Wang AH, Miller CG . The structure of aspartyl dipeptidase reveals a unique fold with a Ser-His-Glu catalytic triad . Proceedings of the National Academy of Sciences of the United States of America . 97 . 26 . 14097–102 . December 2000 . 11106384 . 18877 . 10.1073/pnas.260376797 . 2000PNAS...9714097H . free .
2. Lassy RA, Miller CG . Peptidase E, a peptidase specific for N-terminal aspartic dipeptides, is a serine hydrolase . Journal of Bacteriology . 182 . 9 . 2536–43 . May 2000 . 10762256 . 111318 . 10.1128/jb.182.9.2536-2543.2000 .