Diosmetin Explained

Diosmetin, also known as 5,7,3′-trihydroxy-4′-methoxyflavone, is an O-methylated flavone, a chemical compound that can be found in the Caucasian vetch.^[1]

It has been found to act as a weak TrkB receptor agonist.^[2]

Glycosides

Diosmetin is the aglycone of diosmin.

See also

• Tropomyosin receptor kinase B § Agonists

Notes and References

1. Diosmetin glycosides from caucasian vetch: Isolation and study of biological activity . 10.1007/BF02465832 . 1998 . Andreeva . O. A. . Ivashev . M. N. . Ozimina . I. I. . Maslikova . G. V. . Pharmaceutical Chemistry Journal . 32 . 11 . 595–597 . 21434373 .
2. Jang SW, Liu X, Yepes M, Shepherd KR, Miller GW, Liu Y, Wilson WD, Xiao G, Blanchi B, Sun YE, Ye K . A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone . Proc. Natl. Acad. Sci. U.S.A. . 107 . 6 . 2687–92 . 2010 . 20133810 . 2823863 . 10.1073/pnas.0913572107 . 2010PNAS..107.2687J . free .