Ethylmorphine Explained

Ethylmorphine (also known as codethyline, dionine, and ethyl morphine) is an opioid analgesic and antitussive.^{[1] [2] [3] [4] [5] [6]}

Side effects

Adverse effects are similar to other opioids and include drowsiness, constipation, vertigo, nausea, vomiting, and respiratory depression. Contraindications include asthma, respiratory insufficiency, and age under 8. Ethylmorphine may affect the user's ability to drive and operate heavy machinery, and may cause chemical dependence or addiction at high doses.^[7]

Society and culture

Ethylmorphine was first marketed in France in 1953 by Houde, and in Norway and Spain in 1960. It is not available in the United States, where it is a Schedule II controlled substance.^[8]

See also

• Codeine
• Dihydrocodeine
• Morphine
• Pholcodine

Notes and References

1. Xu BQ, Aasmundstad TA, Lillekjendlie B, Bjørneboe A, Christophersen AS, Mørland J . Effects of ethanol on ethylmorphine metabolism in isolated rat hepatocytes: characterization by means of a multicompartmental model . Pharmacology & Toxicology . 80 . 4 . 171–81 . April 1997 . 9140136 . 10.1111/j.1600-0773.1997.tb00392.x . free .
2. Jonasson B, Jonasson U, Holmgren P, Saldeen T . Fatal poisonings where ethylmorphine from antitussive medications contributed to death . International Journal of Legal Medicine . 112 . 5 . 299–302 . August 1999 . 10460420 . 10.1007/s004140050253 . 24384512 .
3. Popa C, Beck O, Brodin K . Morphine formation from ethylmorphine: implications for drugs-of-abuse testing in urine . Journal of Analytical Toxicology . 22 . 2 . 142–7 . March–April 1998 . 9547411 . 10.1093/jat/22.2.142 . free .
4. Amacher DE, Schomaker SJ . Ethylmorphine N-demethylase activity as a marker for cytochrome P450 CYP3A activity in rat hepatic microsomes . Toxicology Letters . 94 . 2 . 115–25 . January 1998 . 9574808 . 10.1016/S0378-4274(97)00108-2 .
5. Aasmundstad TA, Xu BQ, Johansson I, Ripel A, Bjørneboe A, Christophersen AS, Bodd E, Mørland J . 6 . Biotransformation and pharmacokinetics of ethylmorphine after a single oral dose . British Journal of Clinical Pharmacology . 39 . 6 . 611–20 . June 1995 . 7654478 . 1365072 . 10.1111/j.1365-2125.1995.tb05720.x .
6. Liu Z, Mortimer O, Smith CA, Wolf CR, Rane A . Evidence for a role of cytochrome P450 2D6 and 3A4 in ethylmorphine metabolism . British Journal of Clinical Pharmacology . 39 . 1 . 77–80 . January 1995 . 7756104 . 1364985 . 10.1111/j.1365-2125.1995.tb04413.x .
7. Book: 0-8103-7177-4 . Drugs Available Abroad, 1st Edition . 1991 . 79 . Schlesser JL . Derwent Publications Ltd..
8. Web site: PubChem . Ethylmorphine . 2023-09-08 . pubchem.ncbi.nlm.nih.gov . en.