Dimethylethanolamine Explained

Dimethylethanolamine (DMAE or DMEA) is an organic compound with the formula . It is bifunctional, containing both a tertiary amine and primary alcohol functional groups. It is a colorless viscous liquid. It is used in skin care products for improving skin tone and also taken orally as a nootropic. It is prepared by the ethoxylation of dimethylamine.[1]

Industrial uses

Dimethylaminoethanol is used as a curing agent for polyurethanes and epoxy resins. It is a precursor to other chemicals, such as the nitrogen mustard 2-dimethylaminoethyl chloride.[2] The acrylate ester, dimethylaminoethyl acrylate is used as a flocculating agent.[3]

Related compounds are used in gas purification, e.g. removal of hydrogen sulfide from sour gas streams.

Human uses

The bitartrate salt of DMAE, i.e. N,N-dimethylethanolamine bitartrate, is sold as a dietary supplement.[4] It is a white powder providing 37% DMAE.[5]

Animal tests show possible benefit for improving spatial memory[6] and working memory.[7]

See also

Notes and References

  1. Encyclopedia: Matthias Frauenkron . Johann-Peter Melder . Günther Ruider . Roland Rossbacher . Hartmut Höke . Ethanolamines and Propanolamines. Ullmann's Encyclopedia of Industrial Chemistry. 2002. Wiley-VCH. Weinheim. 10.1002/14356007.a10_001. 978-3-527-30673-2.
  2. Book: Ashford's Dictionary of Industrial Chemicals, 3rd edition . 9780952267430 . 863579691 . 2011 . 3294 . 2023-10-04 . WorldCat.org . Ashford . Robert D. . Wavelength .
  3. Web site: Dimethylaminoethyl Acrylate - Global Review 2020 to 2030 . 2023-10-04 . Fact.MR.
  4. Karen E. . Haneke . Scott . Masten . Dimethylethanolamine (DMAE) [108-01-0] and Selected Salts and Esters: Review of Toxicological Literature (Update) Report on National Institute of Environmental Health Sciences Contract No. N01-ES-65402]. https://web.archive.org/web/20231004110351/https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/chem_background/exsumpdf/dmae_update_110002_508.pdf . 2023-10-04 . live . 2015-04-30 . November 2002 . National Toxicology Program . Contractee Integrated Laboratory Systems, Research Triangle Park, North Carolina, 27709.
  5. Web site: Sigma Aldrich: Safety Data Sheet: 2-Dimethylaminoethanol (+)-bitartrate . live . 2023-10-04 . https://web.archive.org/web/20231004105534/https://www.sigmaaldrich.com/IN/en/sds/aldrich/39000 .
  6. Blin . Olivier . Audebert . Christine . Pitel . Séverine . Kaladjian . Arthur . Casse-Perrot . Catherine . Zaim . Mohammed . Micallef . Joelle . Tisne-Versailles . Jacky . Sokoloff . Pierre . Chopin . Philippe . Marien . Marc . 2009-12-01 . Effects of dimethylaminoethanol pyroglutamate (DMAE p-Glu) against memory deficits induced by scopolamine: evidence from preclinical and clinical studies . Psychopharmacology . en . 207 . 2 . 201–212 . 10.1007/s00213-009-1648-7 . 19756528 . 8535134 . 1432-2072.
  7. Levin . Edward D . Rose . Jed E . Abood . Leo . June 1995 . Effects of nicotinic dimethylaminoethyl esters on working memory performance of rats in the radial-arm maze . Pharmacology Biochemistry and Behavior . en . 51 . 2–3 . 369–373 . 10.1016/0091-3057(94)00406-9. 7667355 . 20685322 .

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