Dimethylamine-corrinoid protein Co-methyltransferase explained

Dimethylamine-corrinoid protein Co-methyltransferase
Ec Number:	2.1.1.249

Dimethylamine-corrinoid protein Co-methyltransferase (mtbB (gene), dimethylamine methyltransferase) is an enzyme with systematic name dimethylamine:5-hydroxybenzimidazolylcobamide Co-methyltransferase.^{[1] [2] [3]} This enzyme catalyses the following chemical reaction

dimethylamine + [Co(I) dimethylamine-specific corrinoid protein]

\rightleftharpoons [methyl-Co(III) dimethylamine-specific corrinoid protein] + methylamine

This enzyme is involved in methanogenesis from dimethylamine.

Notes and References

1. Wassenaar RW, Keltjens JT, van der Drift C, Vogels GD . Purification and characterization of dimethylamine:5-hydroxybenzimidazolyl-cobamide methyltransferase from Methanosarcina barkeri Fusaro . European Journal of Biochemistry . 253 . 3 . 692–7 . May 1998 . 9654067 . 10.1046/j.1432-1327.1998.2530692.x . free .
2. Ferguson DJ, Gorlatova N, Grahame DA, Krzycki JA . Reconstitution of dimethylamine:coenzyme M methyl transfer with a discrete corrinoid protein and two methyltransferases purified from Methanosarcina barkeri . The Journal of Biological Chemistry . 275 . 37 . 29053–60 . September 2000 . 10852929 . 10.1074/jbc.m910218199 . free .
3. Krzycki JA . Function of genetically encoded pyrrolysine in corrinoid-dependent methylamine methyltransferases . Current Opinion in Chemical Biology . 8 . 5 . 484–91 . October 2004 . 15450490 . 10.1016/j.cbpa.2004.08.012 .