Dimethandrolone buciclate explained

Dimethandrolone buciclate (developmental code name CDB-4386A), or dimethandrolone bucyclate, also known as 7α,11β-dimethyl-19-nortestosterone 17β-buciclate, is a synthetic anabolic–androgenic steroid (AAS) and a derivative of nandrolone (19-nortestosterone) which was developed by the Contraceptive Development Branch (CDB) of the National Institute of Child Health and Human Development (NICHD) and has not been marketed at this time.^{[1] [2] [3] [4] [5]} It is an androgen ester – specifically, the C17β buciclate (4-butylcyclohexane-1-carboxylate) ester of dimethandrolone, (7α,11β-dimethyl-19-nortestosterone) – and acts as a prodrug of dimethandrolone in the body. Dimethandrolone buciclate is or was under investigation as a potential male contraceptive.

See also

• List of androgen esters

Notes and References

1. US . 2003069215 . Methods of making and using 7a, 11b-dimethyl-17b-hydroxy-4-estren-3-one 17b-trans-4-n-butylcyclohexane carboxylate and 7a, 11b-dimethyl-17b-hydroxyestr-4-en-3-one 17-undecanoate. . Blye R, Kim H . US Department of Health and Human Services . 10 April 2003 . Abandoned .
2. US . 2005130944 . Method of making and using 7alpha, 11beta-dimethyl-17beta-hydroxyestr-4-en-3-one 17-undecanoate. . Blye R, Kim H . US Department of Health and Human Services . 16 June 2005 . Abandoned .
3. US . 7196074 . Methods of making, using and pharmaceutical formulations comprising 7α, 11β-dimethyl-17β-hydroxyestra-4, 14-dien-3-one and 17 esters thereof . 7 March 2007 . Granted . Blye R, Kim H . US Department of Health and Human Services .
4. US . 2009023695 . Method of making and using 7alpha, 11beta-dimethyl-17beta-hydroxyestr-4-en-3-one 17-undecanoate. . Blye R, Kim H . US Department of Health and Human Services . 22 January 2009 . Abandoned .
5. Brown AE, Sorbera LA . Therapeutic targets for male contraception. Drugs of the Future. 38. 7. 2013. 499. 0377-8282. 10.1358/dof.2013.038.07.1980494. 75204267 .