Dilazep Explained

Dilazep is a vasodilator that acts as an adenosine reuptake inhibitor.^{[1] [2]}

It is used for the treatment of cardiopathy and renal disorders.^[3]

Synthesis

The reaction of bis-(3-hydroxypropyl)-ethylene diamine (1) with 1-Bromo-3-chloropropane (2) gives homopiperazine [19970-80-0] (3). Esterification by reaction with 3,4,5-Trimethoxybenzoyl Chloride [4521-61-3] (4) completed the synthesis of Dilazep (5).

See also

• Hexobendine, a drug with similar chemical structure

Notes and References

1. Deguchi H, Takeya H, Wada H, Gabazza EC, Hayashi N, Urano H, Suzuki K . Dilazep, an antiplatelet agent, inhibits tissue factor expression in endothelial cells and monocytes . Blood . 90 . 6 . 2345–56 . September 1997 . 9310485 . 10.1182/blood.V90.6.2345 . free .
2. Web site: PubChem. Dilazep. 2021-08-18. pubchem.ncbi.nlm.nih.gov. en.
3. Web site: Pharmaceuticals . Kowa Company Ltd. .