Diisononyl phthalate explained

Diisononyl phthalate (DINP) is a phthalate used as a plasticizer. DINP is typically a mixture of chemical compounds consisting of various isononyl esters of phthalic acid, and is commonly used in a large variety of plastic products.

Health Issues

The European Union has set a maximum specific migration limit (SML) from food contact materials of 9 mg/kg food for the sum of diisononyl phthalates and diisodecyl phthalates.^[1]

DINP is listed as a substance "known to the State of California to cause cancer" under Proposition 65 legislation.^[2]

Studies find that exposure to environmentally relevant concentrations of DINP in zebrafish disrupt the endocannabinoid system (ECS) and affect reproduction in a gender specific manner,^[3] and have other adverse effects on aquatic organisms, as DINP upregulates orexigenic signals and causes hepatosteatosis together with deregulation of the peripheral ECS and lipid metabolism.^[4]

The ECHA's Risk Assessment Committee (RAC) has concluded, on March 7, 2018, that Di-isononyl phthalate (DINP) does not warrant classification for reprotoxic effects under the EU's Classification, Labelling and Packaging (CLP) regulations.^[5]

See also

• Diisoheptyl phthalate
• Plastic pollution

Notes and References

1. Web site: EU legislative list for food contact materials.
2. Web site: State of California, Chemicals known to the state to cause cancer or reproductive toxicity, January 3, 2014 . dead . https://web.archive.org/web/20140110153001/http://oehha.ca.gov/prop65/prop65_list/files/P65single01032014.pdf . 2014-01-10 .
3. 2018-10-01. Disruption of the gonadal endocannabinoid system in zebrafish exposed to diisononyl phthalate. Environmental Pollution. en. 241. 1–8. 10.1016/j.envpol.2018.05.007. 29793103. 0269-7491. Forner-Piquer. Isabel. Santangeli. Stefania. Maradonna. Francesca. Rabbito. Alessandro. Piscitelli. Fabiana. Habibi. Hamid R.. Di Marzo. Vincenzo. Carnevali. Oliana. 44120848.
4. Forner-Piquer. Isabel. Maradonna. Francesca. Gioacchini. Giorgia. Santangeli. Stefania. Allarà. Marco. Piscitelli. Fabiana. Habibi. Hamid R. Di Marzo. Vincenzo. Carnevali. Oliana. 2017-08-14. Dose-Specific Effects of Di-Isononyl Phthalate on the Endocannabinoid System and on Liver of Female Zebrafish. Endocrinology. en. 158. 10. 3462–3476. 10.1210/en.2017-00458. 28938452. 0013-7227. free.
5. Web site: Evaluation of new scientific evidence concerning DINP and DIDP . . https://web.archive.org/web/20220901073958/https://echa.europa.eu/documents/10162/31b4067e-de40-4044-93e8-9c9ff1960715 . 2022-09-01 . live . 2020-01-26 .