5α-Dihydrocortisol explained

5α-Dihydrocortisol (5α-DHF), also known as hydrallostane or as allodihydrocortisol,[1] is a metabolite of cortisol that is formed by 5α-reductase.[2] [3] It is present in the aqueous humor of the eye, is produced in the lens of the eye, and is involved in regulating the formation of the aqueous humor. 5α-DHF can be further metabolized into 3α,5α-tetrahydrocortisol by 3α-hydroxysteroid dehydrogenase.

Notes and References

  1. Web site: Hydrallostane.
  2. Azzouni F, Godoy A, Li Y, Mohler J . The 5 alpha-reductase isozyme family: a review of basic biology and their role in human diseases . Adv Urol . 2012 . 530121 . 2012 . 22235201 . 3253436 . 10.1155/2012/530121 . free .
  3. Wilson JD . The role of 5alpha-reduction in steroid hormone physiology . Reprod. Fertil. Dev. . 13 . 7–8 . 673–8 . 2001 . 11999320 . 10.1071/RD01074 .

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