Diethylsuccinoylsuccinate Explained

Diethylsuccinoylsuccinate is an organic compound with the formula [CH<sub>2</sub>C(OH)=C(CO<sub>2</sub>Et)]2 (Et = ethyl). A tetrasubstituted derivative of 1,4-cyclohexadiene, the compound is the enol tautomer of the corresponding cyclohexadione.[1] It is produced by base-induced condensation of diethyl succinate:

2 EtO2CCH2CH2CO2Et [CH<sub>2</sub>C(OH)=C(CO<sub>2</sub>Et)]2 + 2 EtOH

Diethylsuccinylsuccinate is valued as a precursor to the quinacridone pigments. For example, it reacts with two equiv of anilines to give the diamines [CH<sub>2</sub>C(N(H)Ar)=C(CO<sub>2</sub>Et)]2, which undergoes cyclization upon treatment with acid to give dihydroquinacridone.[2] [3]

When heated in the presence of acid, diethylsuccinoylsuccinate converts to 1,4-cyclohexanedione via hydrolysis of the esters followed by decarboxylation.[4]

References

  1. 10.1002/hlca.19730560812. Chemistry of Succinylsuccinic Acid Derivatives. Part II. The crystal and molecular structure of diethyl succinylsuccinate. Helvetica Chimica Acta. 56. 8. 2766–2772. 1973. Mez. Hans-Christian. Rihs. Gret.
  2. 10.1023/B:JOFL.0000016287.56322.eb. Acridones and Quinacridones: Novel Fluorophores for Fluorescence Lifetime Studies. Journal of Fluorescence. 14. 2. 151–171. 2004. Smith. J. Anthony. West. Richard M.. Allen. Malcolm.
  3. 10.1021/cr60245a001. Quinacridones. Chemical Reviews. 67. 1–18. 1967. Labana. S. S.. Labana. L. L..
  4. 10.15227/orgsyn.045.0025. 1,4-Cyclohexanedione. Organic Syntheses. Arnold T.. Nielsen. Wayne R.. Carpenter. 45. 25. 1965.