Dienestrol Explained

Dienestrol (brand names Dienoestrol, Denestrolin, Dienol and many others), also known as dienoestrol, is a synthetic nonsteroidal estrogen medication of the stilbestrol group which is or was used to treat menopausal symptoms in the United States and Europe.^{[1] [2] [3] [4]} It has been studied for use by rectal administration in the treatment of prostate cancer in men as well.^[5] The medication was introduced in the U.S. in 1947 by Schering as Synestrol and in France in 1948 as Cycladiene. Dienestrol is a close analogue of diethylstilbestrol.^[6] It has approximately 223% and 404% of the affinity of estradiol at the ERα and ERβ, respectively.^[7]

Dienestrol diacetate (brand names Faragynol, Gynocyrol, others) also exists and has been used medically.

See also

• Benzestrol
• Hexestrol
• Methestrol

Notes and References

1. Book: Index Nominum 2000: International Drug Directory. January 2000. Taylor & Francis. 978-3-88763-075-1. 331–.
2. Book: J. Elks. The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. 14 November 2014. Springer. 978-1-4757-2085-3. 390–.
3. Book: Muller. European Drug Index: European Drug Registrations, Fourth Edition. 19 June 1998. CRC Press. 978-3-7692-2114-5. 361–.
4. Book: William Andrew Publishing. Pharmaceutical Manufacturing Encyclopedia, 3rd Edition. 22 October 2013. Elsevier. 978-0-8155-1856-3. 1286–.
5. Sambuelli M . Somministrazione degli estrogeni per via rettale nel carcinoma prostatico. . Rectal administration of estrogens in prostate carcinoma . it . Minerva Urol . 5 . 1 . 28–32 . 1953 . 0026-4989 . 13063334 .
6. Book: VITAMINS AND HORMONES. 1 January 1945. Academic Press. 978-0-08-086600-0. 233–.
7. Kuiper GG, Carlsson B, Grandien K, Enmark E, Häggblad J, Nilsson S, Gustafsson JA . Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta . Endocrinology . 138 . 3 . 863–70 . 1997 . 9048584 . 10.1210/endo.138.3.4979 . free .