Dichloroarcyriaflavin A synthase explained

Dichloroarcyriaflavin A synthase
Ec Number:	1.13.12.17

Dichloroarcyriaflavin A synthase is an enzyme with systematic name dichlorochromopyrrolate,NADH:oxygen 2,5-oxidoreductase (dichloroarcyriaflavin A-forming).^{[1] [2] [3]} This enzyme catalyses the following chemical reaction:

dichlorochromopyrrolate + 4 O₂ + 4 NADH + 4 H⁺

\rightleftharpoons dichloroarcyriaflavin A + 2 CO₂ + 6 H₂O + 4 NAD⁺

Notes and References

1. Makino M, Sugimoto H, Shiro Y, Asamizu S, Onaka H, Nagano S . Crystal structures and catalytic mechanism of cytochrome P450 StaP that produces the indolocarbazole skeleton . Proceedings of the National Academy of Sciences of the United States of America . 104 . 28 . 11591–6 . July 2007 . 17606921 . 1913897 . 10.1073/pnas.0702946104 . 2007PNAS..10411591M . free .
2. Howard-Jones AR, Walsh CT . Staurosporine and rebeccamycin aglycones are assembled by the oxidative action of StaP, StaC, and RebC on chromopyrrolic acid . Journal of the American Chemical Society . 128 . 37 . 12289–98 . September 2006 . 16967980 . 10.1021/ja063898m .
3. Sánchez C, Zhu L, Braña AF, Salas AP, Rohr J, Méndez C, Salas JA . Combinatorial biosynthesis of antitumor indolocarbazole compounds . Proceedings of the National Academy of Sciences of the United States of America . 102 . 2 . 461–6 . January 2005 . 15625109 . 544307 . 10.1073/pnas.0407809102 . free .