Dibenzothiophene dihydrodiol dehydrogenase explained

dibenzothiophene dihydrodiol dehydrogenase
Ec Number:	1.3.1.60
Go Code:	0018513

In enzymology, a dibenzothiophene dihydrodiol dehydrogenase is an enzyme that catalyzes the chemical reaction

cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene + NAD⁺

\rightleftharpoons 1,2-dihydroxydibenzothiophene + NADH + H⁺

Thus, the two substrates of this enzyme are cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene and NAD⁺, whereas its 3 products are 1,2-dihydroxydibenzothiophene, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene:NAD+ oxidoreductase.

References

• Laborde AL, Gibson DT . 1977 . Metabolism of dibenzothiophene by a Beijerinckia species . Appl. Environ. Microbiol. . 34 . 783 - 90 . 596875 . 6 . 242748 .
• Denome SA, Stanley DC, Olson ES, Young KD . 1993 . Metabolism of dibenzothiophene and naphthalene in Pseudomonas strains: complete DNA sequence of an upper naphthalene catabolic pathway . J. Bacteriol. . 175 . 6890 - 901 . 8226631 . 21 . 206814 .