Dianol Explained

Dianol is a synthetic, nonsteroidal estrogen that was never marketed.^[1] It is a dimer and impurity of anol, and was, along with hexestrol, involved in erroneous findings of highly potent estrogenic activity with anol.^{[2] [3] [4]} Although a potent estrogen, it requires a dose of 100 μg to show activity, whereas hexestrol shows activity with a mere dose of 0.2 μg.^[5]

See also

• Anethole
• Dianethole
• Diethylstilbestrol
• Stilbestrol

Notes and References

1. Dodds EC . Synthetic œstrogens in treatment. The Irish Journal of Medical Science. 25. 7. 2008. 305–314. 0021-1265. 10.1007/BF02950685. 58062466.
2. Book: Maximov PY, McDaniel RE, Jordan VC . Discovery and Pharmacology of Nonsteroidal Estrogens and Antiestrogens . Tamoxifen: Pioneering Medicine in Breast Cancer. Milestones in Drug Therapy . https://books.google.com/books?id=p-W5BAAAQBAJ&pg=PA3. 23 July 2013. Springer Science & Business Media. 978-3-0348-0664-0 . 10.1007/978-3-0348-0664-0_1 . 3–.
3. Book: Dodds EC . Possibilities in the Realm of Synthetic Estrogens. Harris RS, Thimann KV . Vitamins and Hormones. 1 January 1945 . 3. Academic Press . 978-0-08-086600-0 . 232– . 10.1016/S0083-6729(08)61113-9.
4. Book: Ravina E . Nature as a Source of Drugs: Drugs from Natural Products . The Evolution of Drug Discovery: From Traditional Medicines to Modern Drugs. https://books.google.com/books?id=iDNy0XxGqT8C&pg=PA177 . 11 January 2011. John Wiley & Sons. 978-3-527-32669-3. 177–.
5. Solmssen UV . Synthetic estrogens and the relation between their structure and their activity . Chemical Reviews . 37 . 3 . 481–598 . December 1945 . 21013428 . 10.1021/cr60118a004 .