Diadenosine hexaphosphate hydrolase (ATP-forming) explained

Diadenosine hexaphosphate hydrolase (ATP-forming)
Ec Number:	3.6.1.61

Diadenosine hexaphosphate hydrolase (ATP-forming) (Ndx1) is an enzyme with systematic name P1,P6-bis(5'-adenosyl)hexaphosphate nucleotidohydrolase (ATP-forming).^[1] This enzyme catalyses the following chemical reaction

(1) P1,P6-bis(5'-adenosyl)hexaphosphate + H₂O

\rightleftharpoons 2 ATP

(2) P1,P5-bis(5'-adenosyl)pentaphosphate + H₂O

\rightleftharpoons ATP + ADP

(3) P1,P4-bis(5'-adenosyl)tetraphosphate + H₂O

\rightleftharpoons ATP + AMP

The enzyme requires the presence of the divalent cations (Mn²⁺, Mg²⁺, Zn²⁺, and Co²⁺).

Notes and References

1. Iwai T, Kuramitsu S, Masui R . The Nudix hydrolase Ndx1 from Thermus thermophilus HB8 is a diadenosine hexaphosphate hydrolase with a novel activity . The Journal of Biological Chemistry . 279 . 21 . 21732–9 . May 2004 . 15024014 . 10.1074/jbc.m312018200 . free .