Diacylglycerol cholinephosphotransferase explained

diacylglycerol cholinephosphotransferase
Ec Number:	2.7.8.2
Cas Number:	9026-13-5
Go Code:	0004142

In enzymology, a diacylglycerol cholinephosphotransferase is an enzyme that catalyzes the chemical reaction

CDP-choline + 1,2-diacylglycerol

\rightleftharpoons CMP + a phosphatidylcholine

Thus, the two substrates of this enzyme are CDP-choline and 1,2-diacylglycerol, whereas its two products are CMP and phosphatidylcholine.^[1]

Classification

This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups.

Nomenclature

The systematic name of this enzyme class is CDP choline:1,2-diacylglycerol cholinephosphotransferase. Other names in common use include:

• 1-alkyl-2-acetyl-m-glycerol:CDPcholine choline phosphotransferase,
• 1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase,
• 1-alkyl-2-acetylglycerol cholinephosphotransferase,
• alkylacylglycerol choline phosphotransferase,
• alkylacylglycerol cholinephosphotransferase,
• CDP-choline diglyceride phosphotransferase,
• cholinephosphotransferase,
• CPT,
• cytidine diphosphocholine glyceride transferase,
• cytidine diphosphorylcholine diglyceride transferase,
• diacylglycerol choline phosphotransferase,
• phosphocholine diacylglyceroltransferase,
• phosphorylcholine-glyceride transferase, and
• sn-1,2-diacylglycerol cholinephosphotransferase.

Biological role

This enzyme participates in 3 metabolic pathways: aminophosphonate metabolism, glycerophospholipid metabolism, and ether lipid metabolism.

References

• Lee TC, Blank ML, Fitzgerald V, Snyder F . 1982 . Formation of alkylacyl- and diacylglycerophosphocholines via diradylglycerol cholinephosphotransferase in rat liver . Biochim. Biophys. Acta . 713 . 479 - 83 . 6295501 . 2 . 10.1016/0005-2760(82)90269-7.
• Parthasarathy S, Cady RK, Kraushaar DS, Sladek NE, Baumann WJ . 1978 . Inhibition of diacylglycerol:CDPcholine cholinephosphotransferase activity by dimethylaminoethyl p-chlorophenoxyacetate . Lipids . 13 . 161 - 4 . 204847 . 10.1007/BF02533260 . 2 .
• Renooij W, Snyder F . 1981 . Biosynthesis of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor and a hypotensive lipid) by cholinephosphotransferase in various rat tissues . Biochim. Biophys. Acta . 663 . 545 - 56 . 6260215 . 2 . 10.1016/0005-2760(81)90182-x.

Notes and References

1. Coleman R, Bell RM . 1977 . Phospholipid synthesis in isolated fat cells. Studies of microsomal diacylglycerol cholinephosphotransferase and diacylglycerol ethanolaminephosphotransferase activities . J. Biol. Chem. . 252 . 3050 - 6 . 192727 . 9 .