Dextranomer Explained

Dextranomer (trade name Debrisan, Exudex[1] ) is a cicatrizant used in dressings for wound healing,[2] and in pharmaceutical products to treat fecal incontinence.[3] It consists of dextran polymer chains cross-linked into a three-dimensional network.[4]

Solesta

Solesta is the marketed brand name of a system of injections of dextranomer in stabilized sodium hyaluronate for use in fecal incontinence (FI).[5] This preparation is a biocompatible gel, for use as a perianal injectable bulking agent. The system is intended to be injected in the submucosal layer of the proximal anal canal (i.e. above the level of the dentate line).

Notes and References

  1. Web site: Establishment Registration & Device Listing.
  2. Parulkar BG, Sobti MK, Pardanani DS . Dextranomer dressing in the treatment of infected wounds and cutaneous ulcers . J Postgrad Med . 1985 . 31 . 1 . 28–33. 2413198 .
  3. Web site: Solesta Gel Approved for Fecal Incontinence - Drugs.com MedNews.
  4. http://solestainfo.com/docs/solesta_label.pdf Solesta Package Insert
  5. Hoy. SM. Dextranomer in stabilized sodium hyaluronate (Solesta): in adults with faecal incontinence.. Drugs. Aug 20, 2012. 72. 12. 1671–8. 22845415. 10.2165/11209030-000000000-00000. 6499631.