Desmethylchlorotrianisene Explained

Desmethylchlorotrianisene (DMCTA) is a nonsteroidal estrogen which is thought to be the major active metabolite of chlorotrianisene (CTA; TACE).[1] [2] It is a 1:1 mixture of cis and trans isomers. DMCTA is produced from CTA via mono-O-demethylation catalyzed by cytochrome P450 enzymes in the liver. CTA is thought to act as a long-lasting prodrug of DMCTA.

Notes and References

  1. Ruenitz PC, Toledo MM . Chemical and biochemical characteristics of O-demethylation of chlorotrianisene in the rat . Biochem. Pharmacol. . 30 . 16 . 2203–7 . August 1981 . 7295335 . 10.1016/0006-2952(81)90088-5 .
  2. Book: Virgil Craig Jordan. Estrogen/antiestrogen Action and Breast Cancer Therapy. 1986. Univ of Wisconsin Press. 978-0-299-10480-1. 212.

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