Deschloroketamine Explained

Deschloroketamine (DXE, DCK, 2'-Oxo-PCM) is a dissociative anesthetic^{[1] [2]} that has been sold online as a designer drug.^{[3] [4] [5] [6] [7]} It has also been proposed for the treatment of bacterial, fungal, viral or protozoal infections and for immunomodulation at doses of 2 mg per day.^[8]

Legal status

Deschloroketamine is illegal in Latvia,^[9] and is covered by blanket bans in Canada and the UK.

See also

• Ketamine
• 2-Fluorodeschloroketamine
• 3-Fluorodeschloroketamine
• Bromoketamine
• Methoxmetamine
• Trifluoromethyldeschloroketamine
• Rhynchophylline

Notes and References

1. Robins EG, Zhao Y, Khan I, Wilson A, Luthra SK, Rstad E . Synthesis and in vitro evaluation of (18)F-labelled S-fluoroalkyl diarylguanidines: Novel high-affinity NMDA receptor antagonists for imaging with PET . Bioorganic & Medicinal Chemistry Letters . 20 . 5 . 1749–51 . March 2010 . 20138515 . 10.1016/j.bmcl.2010.01.052 .
2. Aminoketones and methods for their production . US . 3254124 . 31 May 1966 . Stevens CL .
3. Frison G, Zamengo L, Zancanaro F, Tisato F, Traldi P . Characterization of the designer drug deschloroketamine (2-methylamino-2-phenylcyclohexanone) by gas chromatography/mass spectrometry, liquid chromatography/high-resolution mass spectrometry, multistage mass spectrometry, and nuclear magnetic resonance . Rapid Communications in Mass Spectrometry . 30 . 1 . 151–60 . January 2016 . 26661982 . 10.1002/rcm.7425 . 2016RCMS...30..151F . free .
4. Web site: Alerta: descloroketamina vendida como ketamina en Barcelona . Energy Control . Spanish . 2 October 2015.
5. Web site: Los efectos desconocidos de la sequía de ketamina . Vice . 27 March 2015 . 2 October 2015 . Juanjo . Villalba . vanc . Spanish.
6. Web site: Party-drug testing shows its worth . The Medical Republic . 22 October 2015 . Jeremy . Knibbs . vanc .
7. Hájková K, Jurásek B, Čejka J, Štefková K, Páleníček T, Sýkora D, Kuchař M . Synthesis and identification of deschloroketamine metabolites in rats' urine and a quantification method for deschloroketamine and metabolites in rats' serum and brain tissue using liquid chromatography tandem mass spectrometry . Drug Testing and Analysis . October 2019 . 12 . 3 . 343–360 . 31670910 . 10.1002/dta.2726 . 204975994 .
8. Use of 2-methylamino-2-phenylcyclohexanone for the treatment of bacterial, fungal, viral or protozoal infections and for immunomodulation . DE . 4409671 . 23 May 1995 . Preiss D, Tatar A .
9. Web site: Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem . Regulations on Narcotic Drugs, Psychotropic Substances and Precursors Controlled in Latvia . Latvian . Ministry of Health of the Republic of Latvia . 29 October 2015 . 4 March 2016 . https://web.archive.org/web/20160304200229/http://www.vm.gov.lv/images/userfiles/metodiskas_vadlinijas_080914.doc . dead .