Dermatan 4-sulfotransferase explained

Dermatan 4-sulfotransferase
Ec Number:	2.8.2.35

Dermatan 4-sulfotransferase (dermatan-specific N-acetylgalactosamine 4-O-sulfotransferase, dermatan-4-sulfotransferase-1, dermatan-4-sulfotransferase 1, D4ST-1, dermatan N-acetylgalactosamine 4-O-sulfotransferase, CHST14 protein, CHST14) is an enzyme with systematic name 3'-phospho-5'-adenylyl sulfate:(dermatan)-N-acetyl-D-galactosamine 4-sulfotransferase.^{[1] [2] [3] [4]} This enzyme catalyses the following chemical reaction

3'-phospho-5'-adenylyl sulfate + [dermatan]-N-acetyl-D-galactosamine

\rightleftharpoons adenosine 3',5'-bisphosphate + [dermatan]-4-O-sulfo-N-acetyl-D-galactosamine

The sulfation takes place at the 4-position of N-acetyl-D-galactosamine residues of dermatan.

Notes and References

1. Evers MR, Xia G, Kang HG, Schachner M, Baenziger JU . Molecular cloning and characterization of a dermatan-specific N-acetylgalactosamine 4-O-sulfotransferase . The Journal of Biological Chemistry . 276 . 39 . 36344–53 . September 2001 . 11470797 . 10.1074/jbc.M105848200 . free .
2. Mikami T, Mizumoto S, Kago N, Kitagawa H, Sugahara K . Specificities of three distinct human chondroitin/dermatan N-acetylgalactosamine 4-O-sulfotransferases demonstrated using partially desulfated dermatan sulfate as an acceptor: implication of differential roles in dermatan sulfate biosynthesis . The Journal of Biological Chemistry . 278 . 38 . 36115–27 . September 2003 . 12847091 . 10.1074/jbc.M306044200 . free .
3. Pacheco B, Maccarana M, Malmström A . Dermatan 4-O-sulfotransferase 1 is pivotal in the formation of iduronic acid blocks in dermatan sulfate . Glycobiology . 19 . 11 . 1197–203 . November 2009 . 19661164 . 10.1093/glycob/cwp110 . free .
4. Mitsunaga C, Mikami T, Mizumoto S, Fukuda J, Sugahara K . Chondroitin sulfate/dermatan sulfate hybrid chains in the development of cerebellum. Spatiotemporal regulation of the expression of critical disulfated disaccharides by specific sulfotransferases . The Journal of Biological Chemistry . 281 . 28 . 18942–52 . July 2006 . 16702220 . 10.1074/jbc.M510870200 . free .