Derlin-2 Explained

Derlin-2 is a protein that in humans is encoded by the DERL2 gene.^{[1] [2] [3]}

See also

• Derlin-1
• Derlin-3

Further reading

• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . etal. free .
• Lilley BN, Ploegh HL . A membrane protein required for dislocation of misfolded proteins from the ER. . Nature . 429 . 6994 . 834–40 . 2004 . 15215855 . 10.1038/nature02592 . 2004Natur.429..834L . 29483256 .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Lilley BN, Ploegh HL . Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane. . Proc. Natl. Acad. Sci. U.S.A. . 102 . 40 . 14296–301 . 2006 . 16186509 . 10.1073/pnas.0505014102 . 1242303 . free . 2005PNAS..10214296L .
• Oda Y, Okada T, Yoshida H . Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation. . J. Cell Biol. . 172 . 3 . 383–93 . 2006 . 16449189 . 10.1083/jcb.200507057 . 2063648 . etal.
• Rhee S, Grinnell F . Frederick Grinnell (biologist) . P21-activated kinase 1: convergence point in PDGF- and LPA-stimulated collagen matrix contraction by human fibroblasts. . J. Cell Biol. . 172 . 3 . 423–32 . 2006 . 16449192 . 10.1083/jcb.200505175 . 2063651 .
• Maas C, Tagnaouti N, Loebrich S . Neuronal cotransport of glycine receptor and the scaffold protein gephyrin. . J. Cell Biol. . 172 . 3 . 441–51 . 2006 . 16449194 . 10.1083/jcb.200506066 . 2063653 . etal.
• Lilley BN, Gilbert JM, Ploegh HL, Benjamin TL . Murine polyomavirus requires the endoplasmic reticulum protein Derlin-2 to initiate infection. . J. Virol. . 80 . 17 . 8739–44 . 2006 . 16912321 . 10.1128/JVI.00791-06 . 1563856 .

Notes and References

1. Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W . Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics . Genome Res . 10 . 5 . 703–13 . Aug 2000 . 10810093 . 310876 . 10.1101/gr.10.5.703 .
2. Ying H, Yu Y, Xu Y . Cloning and characterization of F-LANa, upregulated in human liver cancer . Biochem Biophys Res Commun . 286 . 2 . 394–400 . Aug 2001 . 11500051 . 10.1006/bbrc.2001.5390 .
3. Web site: Entrez Gene: DERL2 Der1-like domain family, member 2.