| Post: | Deputy Prime Minister |
| Body: | Greece |
| Insignia: | Coat of Arms of Greece (Monochromatic).svg |
| Insigniasize: | 100px |
| Insigniacaption: | Coat of arms of the Greek Government |
| Incumbent: | Vacant |
| Incumbentsince: | 25 May 2023 |
| Department: | Government of Greece |
| Appointer: | Prime Minister of Greece |
| Reports To: | Prime Minister |
| Termlength: | No fixed term |
| Member Of: | Cabinet |
| Inaugural: | Konstantinos Kanaris |
| Website: | Deputy Prime Minister's Office |
The Deputy Prime Minister of Greece (Greek, Modern (1453-);: Αντιπρόεδρος της Κυβερνήσεως, "Vice-President of the Government"; older form: Αντιπρόεδρος του Υπουργικού Συμβουλίου, "Vice-President of the Ministerial Council") is the second senior-most member of the Greek Cabinet. Despite the English translation of the title, he does not actually deputize for the Prime Minister, rather it is a mostly honorific post for senior ministers, and is usually combined with another senior government portfolio (traditionally either Foreign Affairs, Finance or Defence) or a coordinating role over several ministries. The post is not permanent, rather it is created on an ad hoc basis, usually for the leaders of junior parties in coalition cabinets, and may be held by more than one person at once.
The position of the Deputy Prime Minister is currently vacant in Mitsotakis' second cabinet.