Dephospho-(reductase kinase) kinase explained
| dephospho-[reductase kinase] kinase |
| Ec Number: | 2.7.11.3 |
| Cas Number: | 72060-33-4 |
| Go Code: | 0047848 |
In enzymology, a dephospho-[reductase kinase] kinase is an enzyme that catalyzes the chemical reaction
ATP + dephospho-
ADP +
Thus, the two substrates of this enzyme are ATP and dephospho-, whereas its two products are ADP and .
This enzyme belongs to the family of transferases, specifically those transferring a phosphate group to the sidechain oxygen atom of serine or threonine residues in proteins (protein-serine/threonine kinases). The systematic name of this enzyme class is ATP:dephospho- phosphotransferase. Other names in common use include AMP-activated kinase, AMP-activated protein kinase kinase, hydroxymethylglutaryl coenzyme A reductase kinase kinase, hydroxymethylglutaryl coenzyme A reductase kinase kinase, (phosphorylating), reductase kinase, reductase kinase kinase, and STK30.
References
- Beg ZH, Stonik JA, ((Brewer HB Jr)) . 1979 . Characterization and regulation of reductase kinase, a protein kinase that modulates the enzymic activity of 3-hydroxy-3-methylglutaryl-coenzyme A reductase . Proc. Natl. Acad. Sci. U.S.A. . 76 . 4375 - 9 . 291971 . 10.1073/pnas.76.9.4375 . 9 . 411577 . 1979PNAS...76.4375B . free .
- Ingebritsen TS, Lee HS, Parker RA, Gibson DM . 1978 . Reversible modulation of the activities of both liver microsomal hydroxymethylglutaryl coenzyme A reductase and its inactivating enzyme. Evidence for regulation by phosphorylation-dephosphorylation . Biochem. Biophys. Res. Commun. . 81 . 1268 - 77 . 666819 . 10.1016/0006-291X(78)91273-1 . 4 .
- Beg ZH, Stonik JA, ((Brewer HB Jr)) . 1985 . Phosphorylation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase and modulation of its enzymic activity by calcium-activated and phospholipid-dependent protein kinase . J. Biol. Chem. . 260 . 1682 - 7 . 3155737 . 3 . 10.1016/S0021-9258(18)89648-X . free .
- Clarke PR, Hardie DG . 1990 . Regulation of HMG-CoA reductase: identification of the site phosphorylated by the AMP-activated protein kinase in vitro and in intact rat liver . EMBO J. . 9 . 2439 - 46 . 2369897 . 8 . 10.1002/j.1460-2075.1990.tb07420.x . 552270 .
- Sato R, Goldstein JL, Brown MS . 1993 . Replacement of serine-871 of hamster 3-hydroxy-3-methylglutaryl-CoA reductase prevents phosphorylation by AMP-activated kinase and blocks inhibition of sterol synthesis induced by ATP depletion . Proc. Natl. Acad. Sci. U.S.A. . 90 . 9261 - 5 . 8415689 . 10.1073/pnas.90.20.9261 . 20 . 47547 . 1993PNAS...90.9261S . free .
