Deoxyribonuclease (pyrimidine dimer) explained

Deoxyribonuclease (pyrimidine dimer)
Ec Number:3.1.25.1
Cas Number:66143-22-4

Deoxyribonuclease (pyrimidine dimer) (endodeoxyribonuclease (pyrimidine dimer), bacteriophage T4 endodeoxyribonuclease V, T4 endonuclease V) is an enzyme.[1] [2] This enzyme catalyses the following chemical reaction:

Endonucleolytic cleavage near pyrimidine dimers to products with 5'-phosphate

This enzyme acts on a damaged strand, 5' from the damaged site.

Notes and References

  1. Braun AG, Radman M, Grossman L . Enzymatic repair of DNA: SITES OF HYDROLYSIS BY THE Escherichia coli endonuclease specific for pyrimidine dimers (correndonuclease II) . Biochemistry . 15 . 18 . 4116–20 . September 1976 . 786366 . 10.1021/bi00663a031 .
  2. Riazuddin S, Grossman L . Micrococcus luteus correndonucleases. II. Mechanism of action of two endonucleases specific for DNA containing pyrimidine dimers . The Journal of Biological Chemistry . 252 . 18 . 6287–93 . September 1977 . 10.1016/S0021-9258(17)39953-2 . 330526 . free .

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