Deoxyadenosyl radical explained

A deoxyadenosyl radical is a free radical that is structurally related to adenosine by removal of a 5′-hydroxy group from adenosine. This radical occurs in nature as a reactive intermediate. It is generated by radical SAM enzymes and by some varieties of vitamin B12.[1] The deoxyadenosyl radical abstracts hydrogen atoms from substrates, causing rearrangements and other post transcriptional modifications required for biosynthesis.[2]

Notes and References

  1. 2018. Annual Review of Biochemistry. A Rich Man, Poor Man Story of S-Adenosylmethionine and Cobalamin Revisited. Jennifer Bridwell-Rabb . Tsehai A. J. Grell . Catherine L. Drennan . 87. 555–84. 10.1146/annurev-biochem-062917-012500. 29925255. 49354135 .
  2. Broderick, J. B. . Duffus, B. R. . Duschene, K. S. . Shepard, E. M. . Radical S-Adenosylmethionine Enzymes. Chemical Reviews. 2014. 114. 8. 4229–4317. 10.1021/cr4004709. 24476342. 4002137.

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