Denopamine Explained

Denopamine (INN) is a cardiotonic drug which acts as a β₁ adrenergic receptor agonist.^[1] It is used in the treatment of angina^[2] and may also have potential uses in the treatment of congestive heart failure^[3] and for clearing pulmonary oedema.^[4] It is marketed in Japan under the brand name Kalgut (カルグート) and available as tablets of 5 and 10 mg, and 5% fine granules.^[5]

Notes and References

1. Ishide T . Denopamine, a selective beta1-receptor agonist and a new coronary vasodilator . Current Medical Research and Opinion . 18 . 7 . 407–13 . 2002 . 12487507 . 10.1185/030079902125001119 . 25048757 .
2. Nakajima D, Negoro N, Nakaboh A, Nakakoji T, Hoshiga M, Nariyama J, Ishihara T, Hanafusa T . 6 . Effectiveness of low dose denopamine, a beta1-adrenoceptor agonist, in a patient with vasospastic angina refractory to intensive medical treatment . International Journal of Cardiology . 108 . 2 . 281–3 . April 2006 . 15913812 . 10.1016/j.ijcard.2005.03.012 .
3. Nishio R, Matsumori A, Shioi T, Wang W, Yamada T, Ono K, Sasayama S . Denopamine, a beta1-adrenergic agonist, prolongs survival in a murine model of congestive heart failure induced by viral myocarditis: suppression of tumor necrosis factor-alpha production in the heart . Journal of the American College of Cardiology . 32 . 3 . 808–15 . September 1998 . 9741531 . 10.1016/S0735-1097(98)00314-3 . 2433/181223 . free .
4. Sakuma T, Hida M, Nambu Y, Osanai K, Toga H, Takahashi K, Ohya N, Inoue M, Watanabe Y . 6 . Beta1-adrenergic agonist is a potent stimulator of alveolar fluid clearance in hyperoxic rat lungs . Japanese Journal of Pharmacology . 85 . 2 . 161–6 . February 2001 . 11286398 . 10.1254/jjp.85.161 . free .
5. Web site: Kalgut (denopamine) Tablets 5, 10 mg; Fine granules 5%. Full Prescribing Information. Mitsubishi Tanabe Pharma Corporation. 6 March 2016. Japanese.