Demexiptiline Explained

Demexiptiline (brand names Deparon, Tinoran) is a tricyclic antidepressant (TCA) used in France for the treatment of depression.^{[1] [2]} It acts primarily as a norepinephrine reuptake inhibitor similarly to desipramine.^[3]

Synthesis

The ketone dibenzosuberenone (1) is treated with hydroxylamine (2) to give its ketoxime (3). Base-catalyzed alkylation with (4) yields demexiptiline.^{[4] [5]}

Further reading

• Martin A, Masson JM, Jusseaume P, Beloncle M, Voisinet C . [Demexiptiline in the treatment of melancholic states (reflections after 3 years of use)] . fr . Annales médico-psychologiques . 139 . 9 . 1023–35 . November 1981 . 7337336.

Notes and References

1. Book: Swiss Pharmaceutical Society . Index Nominum 2000: International Drug Directory (Book with CD-ROM) . Medpharm Scientific Publishers . Boca Raton . 2000 . 301 . 3-88763-075-0 .
2. Book: Triggle DJ . Dictionary of Pharmacological Agents . Chapman & Hall/CRC . Boca Raton . 1996 . 583 . 0-412-46630-9 .
3. Teste JF, Pelsy-Johann I, Decelle T, Boulu RG . Anti-immobility activity of different antidepressant drugs using the tail suspension test in normal or reserpinized mice . Fundamental & Clinical Pharmacology . 7 . 5 . 219–26 . 1993 . 8370568 . 10.1111/j.1472-8206.1993.tb00235.x. 24240307 .
4. Aichinger G, Behner O, Hoffmeister F, Schütz S . Basic tricyclic oxyiminoethers and their pharmacological properties . Arzneimittel-Forschung . 19 . Suppl 5a:838+ . June 1969 . 5819763 . DE .
5. Basic oximes and their preparation . Schütz S, Behner O, Hoffmeister F . US . 3963778 . 1976-06-15 . Bayer AG .