Demethylrebeccamycin-D-glucose O-methyltransferase explained

Demethylrebeccamycin-D-glucose O-methyltransferase
Ec Number:	2.1.1.164

Demethylrebeccamycin-D-glucose O-methyltransferase (RebM) is an enzyme with systematic name S-adenosyl-L-methionine:demethylrebeccamycin-D-glucose O-methyltransferase.^{[1] [2]} This enzyme catalyses the following chemical reaction

\rightleftharpoons rebeccamycin + S-adenosyl-L-homocysteine

Demethylrebeccamycin-D-glucose O-methyltransferase catalyses the last step in the biosynthesis of rebeccamycin, an indolocarbazole alkaloid produced by the Actinobacterium Lechevalieria aerocolonigenes.

Notes and References

1. Zhang C, Albermann C, Fu X, Peters NR, Chisholm JD, Zhang G, Gilbert EJ, Wang PG, Van Vranken DL, Thorson JS . RebG- and RebM-catalyzed indolocarbazole diversification . ChemBioChem . 7 . 5 . 795–804 . May 2006 . 16575939 . 10.1002/cbic.200500504 . 25017820 .
2. Singh S, McCoy JG, Zhang C, Bingman CA, Phillips GN, Thorson JS . Structure and mechanism of the rebeccamycin sugar 4'-O-methyltransferase RebM . The Journal of Biological Chemistry . 283 . 33 . 22628–36 . August 2008 . 18502766 . 2504894 . 10.1074/jbc.M800503200 . free .