Demethylmenaquinone methyltransferase explained

Demethylmenaquinone methyltransferase
Ec Number:	2.1.1.163

Demethylmenaquinone methyltransferase (S-adenosyl-L-methionine-DMK methyltransferase, demethylmenaquinone C-methylase, 2-heptaprenyl-1,4-naphthoquinone methyltransferase, 2-demethylmenaquinone methyltransferase, S-adenosyl-L-methionine:2-demethylmenaquinone methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:demethylmenaquinone methyltransferase.^{[1] [2] [3] [4]} This enzyme catalyses the following chemical reaction

\rightleftharpoons menaquinol + S-adenosyl-L-homocysteine

The enzyme catalyses the last step in menaquinone biosynthesis.

Notes and References

1. Koike-Takeshita A, Koyama T, Ogura K . Identification of a novel gene cluster participating in menaquinone (vitamin K2) biosynthesis. Cloning and sequence determination of the 2-heptaprenyl-1,4-naphthoquinone methyltransferase gene of Bacillus stearothermophilus . The Journal of Biological Chemistry . 272 . 19 . 12380–3 . May 1997 . 9139683 . 10.1074/jbc.272.19.12380 . free .
2. Wissenbach U, Ternes D, Unden G . An Escherichia coli mutant containing only demethylmenaquinone, but no menaquinone: effects on fumarate, dimethylsulfoxide, trimethylamine N-oxide and nitrate respiration . Archives of Microbiology . 158 . 1 . 68–73 . 1992 . 1444716 . 10.1007/BF00249068 . 5861160 .
3. Catala F, Azerad R, Lederer E . [Properties of demethylmenaquinone C-methylase from Mycobacterium phlei] . Internationale Zeitschrift für Vitaminforschung. International Journal of Vitamin Research. Journal International de Vitaminologie . 40 . 3 . 363–73 . 1970 . 5450997 .
4. Lee PT, Hsu AY, Ha HT, Clarke CF . A C-methyltransferase involved in both ubiquinone and menaquinone biosynthesis: isolation and identification of the Escherichia coli ubiE gene . Journal of Bacteriology . 179 . 5 . 1748–54 . March 1997 . 9045837 . 178890 . 10.1128/jb.179.5.1748-1754.1997.